Ascochlorin derivatives from the leafhopper pathogenic fungus Microcera sp. BCC 17074
Two new ascochlorin derivatives, nectchlorins A ( 1 ) and B ( 2 ), together with eight known compounds ( 3 – 10 ), were isolated from cultures of the leafhopper pathogen Microcera sp. BCC 17074. The structures were elucidated on the basis of NMR spectroscopic and mass spectrometry data. The absolute...
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Published in | Journal of antibiotics Vol. 68; no. 1; pp. 47 - 51 |
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Main Authors | , , , , , |
Format | Journal Article |
Language | English |
Published |
London
Nature Publishing Group UK
01.01.2015
Springer Nature Nature Publishing Group |
Subjects | |
Online Access | Get full text |
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Summary: | Two new ascochlorin derivatives, nectchlorins A (
1
) and B (
2
), together with eight known compounds (
3
–
10
), were isolated from cultures of the leafhopper pathogen
Microcera
sp. BCC 17074. The structures were elucidated on the basis of NMR spectroscopic and mass spectrometry data. The absolute configuration of
2
was determined by application of the modified Mosher’s method. The absolute configuration of LL-Z 1272α epoxide (
9
), which is a plausible biosynthetic precursor of ascochlorins, was established by chemical correlations. Cytotoxic activities of these ascochlorin derivatives were evaluated. |
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Bibliography: | ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 content type line 23 |
ISSN: | 0021-8820 1881-1469 |
DOI: | 10.1038/ja.2014.90 |