Lipocalin-2 mediates non-alcoholic steatohepatitis by promoting neutrophil-macrophage crosstalk via the induction of CXCR2

• Published in: Journal of hepatology Vol. 65; no. 5; pp. 988 - 997
• Main Authors: Ye, Dewei, Yang, Kangmin, Zang, Shufei, Lin, Zhuofeng, Chau, Hau-Tak, Wang, Yudong, Zhang, Jialiang, Shi, Junping, Xu, Aimin, Lin, Shaoqiang, Wang, Yu
• Format: Journal Article
• Language: English
• Published: Netherlands Elsevier B.V 01.11.2016; Elsevier Science Ltd
• Subjects: Animal models; Animals; Chemokines; Cholesterol; Choline; CXCR2 protein; Disease Models, Animal; Extracellular signal-regulated kinase; Fatty liver disease; Gastroenterology and Hepatology; Hepatitis; Hepatocytes; High cholesterol diet; High fat diet; Humans; Inflammation; Leukocyte migration; Leukocytes (neutrophilic); Lipocalin; Lipocalin-2; Liver; Macrophages; MCD diet; Methionine; Mice; Mice, Inbred C57BL; Neutrophils; Non-alcoholic Fatty Liver Disease; Nutrient deficiency; Obesity; Proteins; Receptors, Interleukin-8B; Steatosis; interleukin 1β; NPC; extracellular signal-regulated kinase; MCP-1; tumor necrosis factor α; alanine aminotransferase; monocyte chemoattractant protein-1; ALT; CXCL2; bone marrow transplantation; (C-X-C motif) receptor 2; High fat diet; MCD diet; ASH; CXCR2; HFHC; alcoholic steatohepatitis, AST, aspartate transaminase; Obesity; methionine- and choline-deficient diet; Fatty liver disease; AKO; BMT; DKO; lipocalin 2; Inflammation; IL-1β; NASH; ApoE-LCN2 double knockout; ApoE knockout; MCD; TNF-α; high fat high cholesterol; LCN2; non-parenchymal cell; CXC chemokine ligand-2; ERK; non-alcoholic steatohepatitis
• ISSN: 0168-8278; 1600-0641
• DOI: 10.1016/j.jhep.2016.05.041

Graphical abstract