Functions and Clinical Significance of Super-Enhancers in Bone-Related Diseases

Super-enhancers (SEs) are a large cluster of cis -regulatory DNA elements that contain many binding motifs, which master transcription factors and cofactors bind to with high density. SEs usually regulate the expression of genes that can control the cell identity and fate, and SEs can be used to exp...

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Published inFrontiers in cell and developmental biology Vol. 8; p. 534
Main Authors Qu, Jian, Ouyang, Zhanbo, Wu, Wenqiang, Li, Guohua, Wang, Jiaojiao, Lu, Qiong, Li, Zhihong
Format Journal Article
LanguageEnglish
Published Frontiers Media S.A 30.06.2020
Subjects
bone-related diseases
Cell and Developmental Biology
Ewing sarcoma
multiple myeloma
osteosarcoma
super-enhancers
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Summary:Super-enhancers (SEs) are a large cluster of cis -regulatory DNA elements that contain many binding motifs, which master transcription factors and cofactors bind to with high density. SEs usually regulate the expression of genes that can control the cell identity and fate, and SEs can be used to explain the patterns of the expression of cell-specific genes. Hence, it shows great potential for application in the treatment of diseases like cancer. At present, the clinical treatments for osteosarcoma, Ewing sarcoma, and other bone-related diseases remain challenging. The poor prognosis and difficult treatment of these diseases imposes heavy economic burden on patients and society. In recent years, research on SEs with respect to bone-related diseases has attracted increasing attention. In this paper, we first review the identification and functional mechanisms of SEs. Then, we integrate the findings of the emerging studies on SEs in bone-related diseases. Finally, we summarize recent strategies for targeting SEs for the treatment of bone-related diseases. This review aims to provide comprehensive insights into the roles of SEs in bone-related diseases.
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Edited by: Changjun Li, Xiangya Hospital, Central South University, China
Reviewed by: Liu Yang, Fourth Military Medical University, China; Yu Chai, Southern Medical University, China
These authors have contributed equally to this work
This article was submitted to Molecular Medicine, a section of the journal Frontiers in Cell and Developmental Biology
ISSN:2296-634X
2296-634X
DOI:10.3389/fcell.2020.00534