Rice Bran Derived Bioactive Compounds Modulate Risk Factors of Cardiovascular Disease and Type 2 Diabetes Mellitus: An Updated Review

Cardiovascular disease (CVD) and type 2 diabetes mellitus (T2DM) are two chronic diseases that have claimed more lives globally than any other disease. Dietary supplementation of functional foods containing bioactive compounds is recognised to result in improvements in free-radical-mediated oxidativ...

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Published inNutrients Vol. 11; no. 11; p. 2736
Main Authors Saji, Nancy, Francis, Nidhish, Schwarz, Lachlan J., Blanchard, Christopher L., Santhakumar, Abishek B.
Format Journal Article
LanguageEnglish
Published Switzerland MDPI AG 12.11.2019
MDPI
Subjects
Animals
Antioxidants
bioactive compounds
Cardiovascular disease
cardiovascular diseases
Cardiovascular Diseases - diet therapy
Cardiovascular Diseases - epidemiology
Cardiovascular Diseases - prevention & control
chronic diseases
Cytokines
Diabetes
Diabetes Mellitus, Type 2 - diet therapy
Diabetes Mellitus, Type 2 - epidemiology
Diabetes Mellitus, Type 2 - prevention & control
Diet
Dietary Fiber
dietary supplements
Endothelium
Flavonoids
Free radicals
Functional Food
functional foods
Gene expression
Homeostasis
Humans
Inflammation
Insulin resistance
Lipids
noninsulin-dependent diabetes mellitus
Nutrition
Oryza
Oxidative stress
Peptides
Plant-based beverages
Polyphenols
Proteins
Rats
Review
Rice
rice bran
Risk Factors
Rodents
therapeutics
Tumor necrosis factor-TNF
Australia
type 2 diabetes mellitus
cardiovascular disease
bioactive compounds
rice bran
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Abstract Cardiovascular disease (CVD) and type 2 diabetes mellitus (T2DM) are two chronic diseases that have claimed more lives globally than any other disease. Dietary supplementation of functional foods containing bioactive compounds is recognised to result in improvements in free-radical-mediated oxidative stress. Emerging evidence indicates that bioactive compounds derived from rice bran (RB) have therapeutic potential against cellular oxidative stress. This review aims to describe the mechanistic pathways behind CVD and T2DM development and the therapeutic potential of polyphenols derived from RB against these chronic diseases.
AbstractList After consumption of RB combined with navy bean, a significant increase in lipid metabolites including lysolipid, phospholipids and endocannabinoid N-oleoyltaurine, and a decrease in carnitine was observed [32]. [...]levels of diet-derived amino acids, bioactive chemicals (particularly salicylate) and cofactors/vitamins (e.g., pyridoxal, an active form of vitamin B6) increased compared to the control after RB consumption [32]. Supplementation of interesterified and blended oil of coconut/RB or coconut/sesame oil in male Wistar rats showed a significant decrease in the rate of adenosine diphosphate (ADP) and collagen-induced aggregation of platelets and an increase in the prostacyclin/thromboxane ratio in rat serum [47]. Since platelet aggregation is a critical incident in thrombus formation, the anti-thrombotic effect of RB oil supplementation can have extensive involvement in amelioration of CVD pathological processes. [...]consumption of sesame and RB blended oil for 60 days resulted in a reduction in blood pressure, hyperglycemia and improvements in the lipid profile in hypertensive subjects compared to normotensive subjects [53]. [...]results from all these human dietary intervention studies suggest that the use of blended oils at different proportions as a substitute to a single conventional cooking oil is predicted to be another promising strategy that may help modulate hypertension linked CVD. RB oil supplementation reduced total cholesterol/HDL ratio, non-esterified fatty acids, area under the curve for insulin and hepatic cholesterol.
Cardiovascular disease (CVD) and type 2 diabetes mellitus (T2DM) are two chronic diseases that have claimed more lives globally than any other disease. Dietary supplementation of functional foods containing bioactive compounds is recognised to result in improvements in free-radical-mediated oxidative stress. Emerging evidence indicates that bioactive compounds derived from rice bran (RB) have therapeutic potential against cellular oxidative stress. This review aims to describe the mechanistic pathways behind CVD and T2DM development and the therapeutic potential of polyphenols derived from RB against these chronic diseases.Cardiovascular disease (CVD) and type 2 diabetes mellitus (T2DM) are two chronic diseases that have claimed more lives globally than any other disease. Dietary supplementation of functional foods containing bioactive compounds is recognised to result in improvements in free-radical-mediated oxidative stress. Emerging evidence indicates that bioactive compounds derived from rice bran (RB) have therapeutic potential against cellular oxidative stress. This review aims to describe the mechanistic pathways behind CVD and T2DM development and the therapeutic potential of polyphenols derived from RB against these chronic diseases.
Cardiovascular disease (CVD) and type 2 diabetes mellitus (T2DM) are two chronic diseases that have claimed more lives globally than any other disease. Dietary supplementation of functional foods containing bioactive compounds is recognised to result in improvements in free-radical-mediated oxidative stress. Emerging evidence indicates that bioactive compounds derived from rice bran (RB) have therapeutic potential against cellular oxidative stress. This review aims to describe the mechanistic pathways behind CVD and T2DM development and the therapeutic potential of polyphenols derived from RB against these chronic diseases.
Author Saji, Nancy
Santhakumar, Abishek B.
Blanchard, Christopher L.
Francis, Nidhish
Schwarz, Lachlan J.
AuthorAffiliation 2 School of Biomedical Sciences, Charles Sturt University, Wagga Wagga, NSW 2650, Australia
3 School of Animal and Veterinary Sciences, Charles Sturt University, Wagga Wagga, NSW 2650, Australia
1 Australian Research Council (ARC) Industrial Transformation Training Centre (ITTC) for Functional Grains, Graham Centre for Agricultural Innovation, Charles Sturt University, Wagga Wagga, NSW 2650, Australia; nsaji@csu.edu.au (N.S.); nfrancis@csu.edu.au (N.F.); lschwarz@csu.edu.au (L.J.S.); CBlanchard@csu.edu.au (C.L.B.)
4 School of Agricultural and Wine Sciences, Charles Sturt University, Wagga Wagga, NSW 2650, Australia
AuthorAffiliation_xml – name: 1 Australian Research Council (ARC) Industrial Transformation Training Centre (ITTC) for Functional Grains, Graham Centre for Agricultural Innovation, Charles Sturt University, Wagga Wagga, NSW 2650, Australia; nsaji@csu.edu.au (N.S.); nfrancis@csu.edu.au (N.F.); lschwarz@csu.edu.au (L.J.S.); CBlanchard@csu.edu.au (C.L.B.)
– name: 2 School of Biomedical Sciences, Charles Sturt University, Wagga Wagga, NSW 2650, Australia
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  fullname: Santhakumar, Abishek B.
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Issue 11
Keywords type 2 diabetes mellitus
cardiovascular disease
bioactive compounds
rice bran
Language English
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Snippet Cardiovascular disease (CVD) and type 2 diabetes mellitus (T2DM) are two chronic diseases that have claimed more lives globally than any other disease. Dietary...
After consumption of RB combined with navy bean, a significant increase in lipid metabolites including lysolipid, phospholipids and endocannabinoid...
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SubjectTerms Animals
Antioxidants
bioactive compounds
Cardiovascular disease
cardiovascular diseases
Cardiovascular Diseases - diet therapy
Cardiovascular Diseases - epidemiology
Cardiovascular Diseases - prevention & control
chronic diseases
Cytokines
Diabetes
Diabetes Mellitus, Type 2 - diet therapy
Diabetes Mellitus, Type 2 - epidemiology
Diabetes Mellitus, Type 2 - prevention & control
Diet
Dietary Fiber
dietary supplements
Endothelium
Flavonoids
Free radicals
Functional Food
functional foods
Gene expression
Homeostasis
Humans
Inflammation
Insulin resistance
Lipids
noninsulin-dependent diabetes mellitus
Nutrition
Oryza
Oxidative stress
Peptides
Plant-based beverages
Polyphenols
Proteins
Rats
Review
Rice
rice bran
Risk Factors
Rodents
therapeutics
Tumor necrosis factor-TNF
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Title Rice Bran Derived Bioactive Compounds Modulate Risk Factors of Cardiovascular Disease and Type 2 Diabetes Mellitus: An Updated Review
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Volume 11
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