Rice Bran Derived Bioactive Compounds Modulate Risk Factors of Cardiovascular Disease and Type 2 Diabetes Mellitus: An Updated Review

• Published in: Nutrients Vol. 11; no. 11; p. 2736
• Main Authors: Saji, Nancy, Francis, Nidhish, Schwarz, Lachlan J., Blanchard, Christopher L., Santhakumar, Abishek B.
• Format: Journal Article
• Language: English
• Published: Switzerland MDPI AG 12.11.2019; MDPI
• Subjects: Animals; Antioxidants; bioactive compounds; Cardiovascular disease; cardiovascular diseases; Cardiovascular Diseases - diet therapy; Cardiovascular Diseases - epidemiology; Cardiovascular Diseases - prevention & control; chronic diseases; Cytokines; Diabetes; Diabetes Mellitus, Type 2 - diet therapy; Diabetes Mellitus, Type 2 - epidemiology; Diabetes Mellitus, Type 2 - prevention & control; Diet; Dietary Fiber; dietary supplements; Endothelium; Flavonoids; Free radicals; Functional Food; functional foods; Gene expression; Homeostasis; Humans; Inflammation; Insulin resistance; Lipids; noninsulin-dependent diabetes mellitus; Nutrition; Oryza; Oxidative stress; Peptides; Plant-based beverages; Polyphenols; Proteins; Rats; Review; Rice; rice bran; Risk Factors; Rodents; therapeutics; Tumor necrosis factor-TNF; Australia; type 2 diabetes mellitus; cardiovascular disease; bioactive compounds; rice bran
• ISSN: 2072-6643; 2072-6643
• DOI: 10.3390/nu11112736

Cardiovascular disease (CVD) and type 2 diabetes mellitus (T2DM) are two chronic diseases that have claimed more lives globally than any other disease. Dietary supplementation of functional foods containing bioactive compounds is recognised to result in improvements in free-radical-mediated oxidative stress. Emerging evidence indicates that bioactive compounds derived from rice bran (RB) have therapeutic potential against cellular oxidative stress. This review aims to describe the mechanistic pathways behind CVD and T2DM development and the therapeutic potential of polyphenols derived from RB against these chronic diseases.