Solid Lipid Nanoparticles: Emerging Colloidal Nano Drug Delivery Systems

• Published in: Pharmaceutics Vol. 10; no. 4; p. 191
• Main Authors: Mishra, Vijay, Bansal, Kuldeep K, Verma, Asit, Yadav, Nishika, Thakur, Sourav, Sudhakar, Kalvatala, Rosenholm, Jessica M
• Format: Journal Article
• Language: English
• Published: Switzerland MDPI AG 18.10.2018; MDPI
• Subjects: Bioavailability; Cold; colloidal nanocarriers; Cooling; Crystallization; cytotoxicity; Drug delivery systems; Drugs; Fatty acids; High speed; Homogenization; Lipids; Methods; Microemulsions; Nanoparticles; Particle size; Review; solid lipid nanoparticles; Surfactants; targeted drug delivery; colloidal nanocarriers; targeted drug delivery; cytotoxicity; solid lipid nanoparticles
• ISSN: 1999-4923; 1999-4923
• DOI: 10.3390/pharmaceutics10040191

Solid lipid nanoparticles (SLNs) are nanocarriers developed as substitute colloidal drug delivery systems parallel to liposomes, lipid emulsions, polymeric nanoparticles, and so forth. Owing to their unique size dependent properties and ability to incorporate drugs, SLNs present an opportunity to build up new therapeutic prototypes for drug delivery and targeting. SLNs hold great potential for attaining the goal of targeted and controlled drug delivery, which currently draws the interest of researchers worldwide. The present review sheds light on different aspects of SLNs including fabrication and characterization techniques, formulation variables, routes of administration, surface modifications, toxicity, and biomedical applications.