Prognostic Significance of Lactate Dehydrogenase in Patients Undergoing Surgical Resection for Laryngeal Squamous Cell Carcinoma

The aim is to estimate the prognostic value of lactate dehydrogenase (LDH) in patients undergoing surgical resection for laryngeal squamous cell carcinoma (LSCC). A total of 640 resected LSCC patients were included. Preoperative lactate dehydrogenase (LDH) was assessed. Kaplan-Meier survival analysi...

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Published inCancer control Vol. 27; no. 1; p. 1073274820978795
Main Authors Guo, Erliang, Guo, Lunhua, An, Changming, Zhang, Cong, Song, Kaibin, Wang, Guohui, Duan, Chunbin, Zhang, Xiwei, Yang, Xianguang, Yuan, Zhennan, Guo, Junnan, Sun, Ji, Meng, Hongxue, Chang, Rui, Li, Xiaomei, Xiu, Cheng, Mao, Xionghui, Miao, Susheng
Format Journal Article
LanguageEnglish
Published Los Angeles, CA SAGE Publications 01.10.2020
Sage Publications Ltd
SAGE Publishing
Subjects
Dehydrogenases
L-Lactate dehydrogenase
Lactic acid
Laryngeal cancer
Multivariate analysis
Original Research Paper
Squamous cell carcinoma
Survival analysis
lactate dehydrogenase
overall survival
laryngeal cancer
recurrence-free survival
prognosis
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Abstract The aim is to estimate the prognostic value of lactate dehydrogenase (LDH) in patients undergoing surgical resection for laryngeal squamous cell carcinoma (LSCC). A total of 640 resected LSCC patients were included. Preoperative lactate dehydrogenase (LDH) was assessed. Kaplan-Meier survival analysis and Cox regression analysis were conducted for overall survival (OS) and recurrence-free survival (RFS). Kaplan-Meier analysis, univariate analysis and multivariate analysis demonstrated significant prognostic value for preoperative LDH. Although LDH was predictor of OS, it failed to be a predictor of RFS. The univariate HR and 95% CI of LDH were 0.484 and 0.357-0.658 (P < 0.0001). The multivariate analysis showed that LDH (HR = 0.518, 95% CI: 0.380-0.705, p < 0.0001) was related to OS. Elevated preoperative LDH >132 IU/L was significantly associated with better survival. Preoperative LDH might be an independent prognostic marker of OS in LSCC patients undergoing surgical resection.
AbstractList The aim is to estimate the prognostic value of lactate dehydrogenase (LDH) in patients undergoing surgical resection for laryngeal squamous cell carcinoma (LSCC). A total of 640 resected LSCC patients were included. Preoperative lactate dehydrogenase (LDH) was assessed. Kaplan-Meier survival analysis and Cox regression analysis were conducted for overall survival (OS) and recurrence-free survival (RFS). Kaplan-Meier analysis, univariate analysis and multivariate analysis demonstrated significant prognostic value for preoperative LDH. Although LDH was predictor of OS, it failed to be a predictor of RFS. The univariate HR and 95% CI of LDH were 0.484 and 0.357-0.658 (P < 0.0001). The multivariate analysis showed that LDH (HR = 0.518, 95% CI: 0.380-0.705, p < 0.0001) was related to OS. Elevated preoperative LDH >132 IU/L was significantly associated with better survival. Preoperative LDH might be an independent prognostic marker of OS in LSCC patients undergoing surgical resection.
Author An, Changming
Meng, Hongxue
Zhang, Xiwei
Zhang, Cong
Song, Kaibin
Li, Xiaomei
Xiu, Cheng
Duan, Chunbin
Yuan, Zhennan
Yang, Xianguang
Sun, Ji
Wang, Guohui
Miao, Susheng
Chang, Rui
Mao, Xionghui
Guo, Junnan
Guo, Lunhua
Guo, Erliang
AuthorAffiliation 1 Department of Surgery, The 2nd Affiliated Hospital of Harbin Medical University, Harbin 150081, China
3 Department of Head and Neck Surgery, Chinese National Cancer Center & Chinese Academy of Medical Sciences Cancer Hospital. Beijing 100000, China
2 Department of Head and Neck Surgery, Harbin Medical University Cancer Hospital, Harbin 150081, China
5 Department of Head and Neck Surgery, Anyang Cancer Hospital, Anyang 455000, China
4 Department of Pathology, Harbin Medical University Cancer Hospital, Harbin 150081, China
These two authors have contributed equally to the work
AuthorAffiliation_xml – name: 1 Department of Surgery, The 2nd Affiliated Hospital of Harbin Medical University, Harbin 150081, China
– name: 5 Department of Head and Neck Surgery, Anyang Cancer Hospital, Anyang 455000, China
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– name: 3 Department of Head and Neck Surgery, Chinese National Cancer Center & Chinese Academy of Medical Sciences Cancer Hospital. Beijing 100000, China
– name: These two authors have contributed equally to the work
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CitedBy_id crossref_primary_10_1002_cam4_5697
crossref_primary_10_1016_j_semcancer_2022_11_007
Cites_doi 10.1371/journal.pone.0074853
10.1021/acs.jmedchem.5b00168
10.1159/000449138
10.1093/annonc/mdx333
10.1016/j.ccr.2006.04.023
10.1111/jop.12374
10.3109/0284186X.2015.1043026
10.1007/s11523-011-0184-7
10.1007/s12013-012-9482-7
10.1016/j.ejca.2013.03.008
10.3322/caac.21338
10.1017/S002221511600880X
10.1016/j.ygeno.2015.03.001
10.1371/journal.pone.0057697
10.1186/s12885-016-2276-3
10.1111/bpa.12299
10.1002/jnr.23994
10.1186/1476-4598-9-33
10.3233/CBM-160580
10.1016/j.ctarc.2019.100151
10.1158/1078-0432.CCR-12-1397
10.1016/j.jbo.2015.09.002
10.1007/978-1-4614-8354-0_20
10.1186/1746-1596-5-22
10.21037/jtd.2016.08.56
10.1158/1078-0432.CCR-10-2918
10.21037/jtd.2018.02.16
10.1007/s00106-017-0391-3
10.1016/j.devcel.2010.05.012
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Issue 1
Keywords lactate dehydrogenase
overall survival
laryngeal cancer
recurrence-free survival
prognosis
Language English
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References Grimm, Krimmel, Hoefert 2016; 45
Egeblad, Nakasone, Werb 2010; 18
Lu, Jiang, Chen 2013; 8
Santos, Estevao, Antunes, Certal, Silva, Monteiro 2016; 130
Zhou, Xie, Shao 2018; 10
Wan, Wei, Li 2013; 49
Asgari, Zabihinpour, Salehzadeh-Yazdi, Schreiber, Masoudi-Nejad 2015; 105
Nikolin, Djan, Trifunovic 2016; 21
Bak, Schousboe 2017; 95
Rani, Kumar 2016; 59
Li, Wang, Xu, Wu, Cai, He 2016; 16
Brown, Cook, Lipton, Coleman 2012; 18
Langhammer, Najjar, Hess-Stumpp, Thierauch 2011; 6
Brown, Higham, Perunovic, Arafa, Balasubramanian, Rehman 2013; 8
Marais, Bertie, Rodseth, Sartorius, Ferreira 2015; 4
Ranasinghe, Cotogno, Ledet 2019; 20
Doescher, Veit, Hoffmann 2017; 65
Zhou, Zhao, Ding 2010; 9
Kayser, Kassem, Sienel 2010; 5
Fantin, St-Pierre, Leder 2006; 9
Radenkovic, Milosevic, Konjevic 2013; 66
Abrisqueta, Scott, Slack 2017; 28
Chen, Zheng, Baade 2016; 66
Koukourakis, Giatromanolaki, Sivridis 2011; 17
Yuan, Gao, Mu 2016; 8
Valvona, Fillmore, Nunn, Pilkington 2016; 26
Chen, Wei, Oncology 2015
Zhang, Guo, Fan 2016; 16
Petrelli, Cabiddu, Coinu 2015; 54
Zhang, Xu, Wang 2016; 39
bibr18-1073274820978795
Chen W (bibr19-1073274820978795) 2015
Nikolin B (bibr20-1073274820978795) 2016; 21
bibr30-1073274820978795
bibr9-1073274820978795
bibr21-1073274820978795
bibr14-1073274820978795
bibr5-1073274820978795
bibr12-1073274820978795
bibr27-1073274820978795
bibr25-1073274820978795
bibr31-1073274820978795
bibr17-1073274820978795
bibr4-1073274820978795
bibr22-1073274820978795
bibr26-1073274820978795
bibr8-1073274820978795
bibr13-1073274820978795
bibr7-1073274820978795
bibr24-1073274820978795
bibr2-1073274820978795
bibr16-1073274820978795
bibr23-1073274820978795
bibr3-1073274820978795
bibr29-1073274820978795
bibr10-1073274820978795
bibr1-1073274820978795
bibr15-1073274820978795
bibr28-1073274820978795
bibr6-1073274820978795
bibr11-1073274820978795
References_xml – year: 2015
  article-title: Value of serum LDH, TPS, CEA and β2-MG in the diagnosis of non-Hodgkin’s lymphoma
  publication-title: J Mol Imaging
  contributor:
    fullname: Oncology
– volume: 66
  start-page: 115
  issue: 2
  year: 2016
  end-page: 132
  article-title: Cancer statistics in China, 2015
  publication-title: CA Cancer J Clin
  contributor:
    fullname: Baade
– volume: 66
  start-page: 287
  issue: 2
  year: 2013
  end-page: 295
  article-title: Lactate dehydrogenase, catalase, and superoxide dismutase in tumor tissue of breast cancer patients in respect to mammographic findings
  publication-title: Cell Biochem Biophys
  contributor:
    fullname: Konjevic
– volume: 16
  start-page: 415
  issue: 3
  year: 2016
  end-page: 423
  article-title: Prognostic significance of serum LDH in small cell lung cancer: a systematic review with meta-analysis
  publication-title: Cancer Biomark
  contributor:
    fullname: Fan
– volume: 17
  start-page: 4892
  issue: 14
  year: 2011
  end-page: 4900
  article-title: Prognostic and predictive role of lactate dehydrogenase 5 expression in colorectal cancer patients treated with PTK787/ZK 222584 (vatalanib) antiangiogenic therapy
  publication-title: Clin Cancer Res
  contributor:
    fullname: Sivridis
– volume: 18
  start-page: 884
  issue: 6
  year: 2010
  end-page: 901
  article-title: Tumors as organs: complex tissues that interface with the entire organism
  publication-title: Dev Cell
  contributor:
    fullname: Werb
– volume: 9
  start-page: 33
  year: 2010
  article-title: Warburg effect in chemosensitivity: targeting lactate dehydrogenase-A re-sensitizes taxol-resistant cancer cells to taxol
  publication-title: Mol Cancer
  contributor:
    fullname: Ding
– volume: 95
  start-page: 2098
  issue: 11
  year: 2017
  end-page: 2102
  article-title: Misconceptions regarding basic thermodynamics and enzyme kinetics have led to erroneous conclusions regarding the metabolic importance of lactate dehydrogenase isoenzyme expression
  publication-title: J Neurosci Res
  contributor:
    fullname: Schousboe
– volume: 10
  start-page: 1043
  issue: 2
  year: 2018
  end-page: 1049
  article-title: Modeling the relationship between baseline lactate dehydrogenase and prognosis in patients with extensive-disease small cell lung cancer: a retrospective cohort study
  publication-title: J Thorac Dis
  contributor:
    fullname: Shao
– volume: 9
  start-page: 425
  issue: 6
  year: 2006
  end-page: 434
  article-title: Attenuation of LDH-A expression uncovers a link between glycolysis, mitochondrial physiology, and tumor maintenance
  publication-title: Cancer Cell
  contributor:
    fullname: Leder
– volume: 105
  start-page: 275
  year: 2015
  end-page: 281
  article-title: Alterations in cancer cell metabolism: the Warburg effect and metabolic adaptation
  publication-title: Genomics
  contributor:
    fullname: Masoudi-Nejad
– volume: 20
  start-page: 100151
  year: 2019
  article-title: Relationship between serum markers and volume of liver metastases in castration-resistant prostate cancer
  publication-title: Cancer Treat Res Commun
  contributor:
    fullname: Ledet
– volume: 8
  start-page: e74853
  issue: 9
  year: 2013
  article-title: Lactate dehydrogenase 5 expression in Non-Hodgkin lymphoma is associated with the induced hypoxia regulated protein and poor prognosis
  publication-title: PLoS One
  contributor:
    fullname: Chen
– volume: 6
  start-page: 155
  issue: 3
  year: 2011
  end-page: 162
  article-title: LDH-A influences hypoxia-inducible factor 1alpha (HIF1 alpha) and is critical for growth of HT29 colon carcinoma cells in vivo
  publication-title: Target Oncol
  contributor:
    fullname: Thierauch
– volume: 28
  start-page: 2489
  issue: 10
  year: 2017
  end-page: 2495
  article-title: Observation as the initial management strategy in patients with mantle cell lymphoma
  publication-title: Ann Oncol
  contributor:
    fullname: Slack
– volume: 39
  start-page: 592
  issue: 10
  year: 2016
  end-page: 604
  article-title: Prognostic role of lactate dehydrogenase expression in urologic cancers: a systematic review and meta-analysis
  publication-title: Oncol Res Treat
  contributor:
    fullname: Wang
– volume: 45
  start-page: 346
  issue: 5
  year: 2016
  end-page: 355
  article-title: Monitoring a ‘metabolic shift’ after surgical resection of oral squamous cell carcinomas by serum lactate dehydrogenase
  publication-title: J Oral Pathol Med
  contributor:
    fullname: Hoefert
– volume: 8
  start-page: e57697
  issue: 2
  year: 2013
  article-title: Lactate dehydrogenase-B is silenced by promoter methylation in a high frequency of human breast cancers
  publication-title: PLoS One
  contributor:
    fullname: Rehman
– volume: 16
  start-page: 249
  year: 2016
  article-title: The prognostic value of lactate dehydrogenase levels in colorectal cancer: a meta-analysis
  publication-title: BMC Cancer
  contributor:
    fullname: He
– volume: 49
  start-page: 2356
  issue: 10
  year: 2013
  end-page: 2364
  article-title: High pretreatment serum lactate dehydrogenase level correlates with disease relapse and predicts an inferior outcome in locally advanced nasopharyngeal carcinoma
  publication-title: Eur J Cancer
  contributor:
    fullname: Li
– volume: 18
  start-page: 6348
  issue: 22
  year: 2012
  end-page: 6355
  article-title: Serum lactate dehydrogenase is prognostic for survival in patients with bone metastases from breast cancer: a retrospective analysis in bisphosphonate-treated patients
  publication-title: Clin Cancer Res
  contributor:
    fullname: Coleman
– volume: 8
  start-page: 2464
  issue: 9
  year: 2016
  end-page: 2472
  article-title: Prognostic value of preoperative serum lactate dehydrogenase in thymic carcinoma
  publication-title: J Thorac Dis
  contributor:
    fullname: Mu
– volume: 59
  start-page: 487
  issue: 2
  year: 2016
  end-page: 496
  article-title: Recent update on human lactate dehydrogenase enzyme 5 (hLDH5) inhibitors: a promising approach for cancer chemotherapy
  publication-title: J Med Chem
  contributor:
    fullname: Kumar
– volume: 21
  start-page: 691
  issue: 3
  year: 2016
  end-page: 697
  article-title: MIA, S100 and LDH as important predictors of overall survival of patients with stage IIb and IIc melanoma
  publication-title: J BUON
  contributor:
    fullname: Trifunovic
– volume: 26
  start-page: 3
  issue: 1
  year: 2016
  end-page: 17
  article-title: The regulation and function of lactate dehydrogenase A: therapeutic potential in brain tumor
  publication-title: Brain Pathol
  contributor:
    fullname: Pilkington
– volume: 54
  start-page: 961
  issue: 7
  year: 2015
  end-page: 970
  article-title: Prognostic role of lactate dehydrogenase in solid tumors: a systematic review and meta-analysis of 76 studies
  publication-title: Acta Oncol
  contributor:
    fullname: Coinu
– volume: 5
  start-page: 22
  year: 2010
  article-title: Lactate-dehydrogenase 5 is overexpressed in non-small cell lung cancer and correlates with the expression of the transketolase-like protein 1
  publication-title: Diagn Pathol
  contributor:
    fullname: Sienel
– volume: 4
  start-page: 80
  issue: 3
  year: 2015
  end-page: 84
  article-title: Pre-treatment serum lactate dehydrogenase and alkaline phosphatase as predictors of metastases in extremity osteosarcoma
  publication-title: J Bone Oncol
  contributor:
    fullname: Ferreira
– volume: 130
  start-page: 948
  issue: 10
  year: 2016
  end-page: 953
  article-title: Clinical and histopathological prognostic factors in locoregional advanced laryngeal cancer
  publication-title: J Laryngol Otol
  contributor:
    fullname: Monteiro
– volume: 65
  start-page: 956
  issue: 12
  year: 2017
  end-page: 961
  article-title: [The 8th edition of the AJCC Cancer Staging Manual: updates in otorhinolaryngology, head and neck surgery]
  publication-title: HNO
  contributor:
    fullname: Hoffmann
– ident: bibr17-1073274820978795
  doi: 10.1371/journal.pone.0074853
– ident: bibr4-1073274820978795
  doi: 10.1021/acs.jmedchem.5b00168
– ident: bibr9-1073274820978795
  doi: 10.1159/000449138
– ident: bibr18-1073274820978795
  doi: 10.1093/annonc/mdx333
– year: 2015
  ident: bibr19-1073274820978795
  publication-title: J Mol Imaging
  contributor:
    fullname: Chen W
– ident: bibr5-1073274820978795
  doi: 10.1016/j.ccr.2006.04.023
– ident: bibr16-1073274820978795
  doi: 10.1111/jop.12374
– ident: bibr7-1073274820978795
  doi: 10.3109/0284186X.2015.1043026
– ident: bibr27-1073274820978795
  doi: 10.1007/s11523-011-0184-7
– ident: bibr30-1073274820978795
  doi: 10.1007/s12013-012-9482-7
– ident: bibr24-1073274820978795
  doi: 10.1016/j.ejca.2013.03.008
– ident: bibr1-1073274820978795
  doi: 10.3322/caac.21338
– ident: bibr3-1073274820978795
  doi: 10.1017/S002221511600880X
– ident: bibr14-1073274820978795
  doi: 10.1016/j.ygeno.2015.03.001
– ident: bibr28-1073274820978795
  doi: 10.1371/journal.pone.0057697
– ident: bibr8-1073274820978795
  doi: 10.1186/s12885-016-2276-3
– ident: bibr15-1073274820978795
  doi: 10.1111/bpa.12299
– ident: bibr29-1073274820978795
  doi: 10.1002/jnr.23994
– ident: bibr31-1073274820978795
  doi: 10.1186/1476-4598-9-33
– ident: bibr21-1073274820978795
  doi: 10.3233/CBM-160580
– ident: bibr25-1073274820978795
  doi: 10.1016/j.ctarc.2019.100151
– ident: bibr26-1073274820978795
  doi: 10.1158/1078-0432.CCR-12-1397
– ident: bibr11-1073274820978795
  doi: 10.1016/j.jbo.2015.09.002
– ident: bibr2-1073274820978795
  doi: 10.1007/978-1-4614-8354-0_20
– ident: bibr6-1073274820978795
  doi: 10.1186/1746-1596-5-22
– ident: bibr10-1073274820978795
  doi: 10.21037/jtd.2016.08.56
– volume: 21
  start-page: 691
  issue: 3
  year: 2016
  ident: bibr20-1073274820978795
  publication-title: J BUON.
  contributor:
    fullname: Nikolin B
– ident: bibr23-1073274820978795
  doi: 10.1158/1078-0432.CCR-10-2918
– ident: bibr22-1073274820978795
  doi: 10.21037/jtd.2018.02.16
– ident: bibr12-1073274820978795
  doi: 10.1007/s00106-017-0391-3
– ident: bibr13-1073274820978795
  doi: 10.1016/j.devcel.2010.05.012
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Snippet The aim is to estimate the prognostic value of lactate dehydrogenase (LDH) in patients undergoing surgical resection for laryngeal squamous cell carcinoma...
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SubjectTerms Dehydrogenases
L-Lactate dehydrogenase
Lactic acid
Laryngeal cancer
Multivariate analysis
Original Research Paper
Squamous cell carcinoma
Survival analysis
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Title Prognostic Significance of Lactate Dehydrogenase in Patients Undergoing Surgical Resection for Laryngeal Squamous Cell Carcinoma
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Volume 27
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