Prognostic Significance of Lactate Dehydrogenase in Patients Undergoing Surgical Resection for Laryngeal Squamous Cell Carcinoma

• Published in: Cancer control Vol. 27; no. 1; pp. 107327482097879 - 1073274820978795
• Main Authors: Guo, Erliang, Guo, Lunhua, An, Changming, Zhang, Cong, Song, Kaibin, Wang, Guohui, Duan, Chunbin, Zhang, Xiwei, Yang, Xianguang, Yuan, Zhennan, Guo, Junnan, Sun, Ji, Meng, Hongxue, Chang, Rui, Li, Xiaomei, Xiu, Cheng, Mao, Xionghui, Miao, Susheng
• Format: Journal Article
• Language: English
• Published: Los Angeles, CA SAGE Publications 2020; Sage Publications Ltd; SAGE Publishing
• Subjects: Dehydrogenases; L-Lactate dehydrogenase; Lactic acid; Laryngeal cancer; Multivariate analysis; Original Research Paper; Squamous cell carcinoma; Survival analysis; lactate dehydrogenase; overall survival; laryngeal cancer; recurrence-free survival; prognosis
• ISSN: 1073-2748; 1526-2359; 1073-2748
• DOI: 10.1177/1073274820978795

The aim is to estimate the prognostic value of lactate dehydrogenase (LDH) in patients undergoing surgical resection for laryngeal squamous cell carcinoma (LSCC). A total of 640 resected LSCC patients were included. Preoperative lactate dehydrogenase (LDH) was assessed. Kaplan-Meier survival analysis and Cox regression analysis were conducted for overall survival (OS) and recurrence-free survival (RFS). Kaplan-Meier analysis, univariate analysis and multivariate analysis demonstrated significant prognostic value for preoperative LDH. Although LDH was predictor of OS, it failed to be a predictor of RFS. The univariate HR and 95% CI of LDH were 0.484 and 0.357-0.658 (P < 0.0001). The multivariate analysis showed that LDH (HR = 0.518, 95% CI: 0.380-0.705, p < 0.0001) was related to OS. Elevated preoperative LDH >132 IU/L was significantly associated with better survival. Preoperative LDH might be an independent prognostic marker of OS in LSCC patients undergoing surgical resection.