Palladium-catalyzed intramolecular C–H arylation of 2-halo- N -Boc- N -arylbenzamides for the synthesis of N–H phenanthridinones

• Published in: RSC advances Vol. 8; no. 25; pp. 13879 - 13890
• Main Authors: Hu, Quan-Fang, Gao, Tian-Tao, Shi, Yao-Jie, Lei, Qian, Yu, Luo-Ting
• Format: Journal Article
• Language: English
• Published: England Royal Society of Chemistry 01.01.2018; The Royal Society of Chemistry
• Subjects: arylation; catalytic activity; Chemical synthesis; Chemistry; Palladium; regioselectivity; Substrates

A palladium catalyzed synthesis of N–H phenanthridinones was developed via C–H arylation. The protocol gives phenanthridinones regioselectively by one-pot reaction without deprotection. It exhibits broad substrate scope and affords targets in up to 95% yields. Importantly, it could be applied for th...