Palladium-catalyzed intramolecular C–H arylation of 2-halo- N -Boc- N -arylbenzamides for the synthesis of N–H phenanthridinones

A palladium catalyzed synthesis of N–H phenanthridinones was developed via C–H arylation. The protocol gives phenanthridinones regioselectively by one-pot reaction without deprotection. It exhibits broad substrate scope and affords targets in up to 95% yields. Importantly, it could be applied for th...

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Published inRSC advances Vol. 8; no. 25; pp. 13879 - 13890
Main Authors Hu, Quan-Fang, Gao, Tian-Tao, Shi, Yao-Jie, Lei, Qian, Yu, Luo-Ting
Format Journal Article
LanguageEnglish
Published England Royal Society of Chemistry 01.01.2018
The Royal Society of Chemistry
Subjects
arylation
catalytic activity
Chemical synthesis
Chemistry
Palladium
regioselectivity
Substrates
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Summary:A palladium catalyzed synthesis of N–H phenanthridinones was developed via C–H arylation. The protocol gives phenanthridinones regioselectively by one-pot reaction without deprotection. It exhibits broad substrate scope and affords targets in up to 95% yields. Importantly, it could be applied for the less reactive o -chlorobenzamides.
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ISSN:2046-2069
2046-2069
DOI:10.1039/C8RA02099J