Effect of Genetic Polymorphism +294T/C in Peroxisome Proliferator-Activated Receptor Delta on the Risk of Ischemic Stroke in a Tunisian Population

• Published in: Journal of molecular neuroscience Vol. 50; no. 2; pp. 360 - 367
• Main Authors: Chehaibi, Khouloud, Hrira, Mohamed Yahia, Rouis, Mustapha, Najah, Mohamed, Jguirim-Souissi, Imen, Nouira, Samir, Slimane, Mohamed Naceur
• Format: Journal Article
• Language: English
• Published: New York Humana Press Inc 01.06.2013; Springer Nature B.V; Humana Press
• Subjects: Aged; Alleles; Atherosclerosis; Biomedical and Life Sciences; Biomedicine; Blood vessels; Body Mass Index; Brain Ischemia - complications; Brain Ischemia - genetics; Cardiovascular disease; Case-Control Studies; Cell Biology; Cellular Biology; Cholesterol; Cholesterol, HDL - blood; Cholesterol, LDL - blood; Diabetes; Diabetes Complications - genetics; Female; Genes; Genetic Association Studies; Genetic Predisposition to Disease; Genotype; Health risk assessment; High density lipoprotein; Humans; Inflammation; Ischemia; Life Sciences; Ligands; Lipids; Lipoproteins; Male; Metabolism; Middle Aged; Neurochemistry; Neurology; Neurosciences; Polymorphism; Polymorphism, Single Nucleotide; PPAR delta - genetics; Proteomics; Risk factors; Smooth muscle; Stroke; Stroke - complications; Stroke - genetics; Thrombosis; Triglycerides; Triglycerides - blood; Tunisia; Tunisia; Diabetes; Ischemic stroke; PPARδ; Polymorphism; PPAR delta
• ISSN: 0895-8696; 1559-1166; 1559-1166
• DOI: 10.1007/s12031-013-9997-4

PPARδ +294T/C polymorphism was investigated in diabetics, in normolipidemic healthy controls, in dyslipidemic and nondyslipidemic coronary artery disease patients but never in ischemic stroke patients. The aim of this study was to explore, for the first time, the relationship between the genetic polymorphism of PPARδ and the risk of ischemic stroke among patients with diabetes. The study group consisted of 196 patients with ischemic stroke and 192 controls. Plasma concentrations of total cholesterol, triglycerides, low-, and high-density lipoprotein did not differ significantly between subjects carrying the TT genotype and those carrying the CC/TC genotype in both ischemic stroke patients (with or without diabetes) and control groups. The +294C allele (CC + CT genotypes) as compared with TT genotypes was found to be higher in total ischemic stroke patients than in controls. On the other hand, no interaction between diabetes and PPAR +294T/C polymorphism on the risk of ischemic stroke was found ( p  = 0.089). The PPARδ +294T/C polymorphism was associated with the risk of ischemic stroke in Tunisian subjects. This polymorphism has no influence on plasma lipoprotein concentrations and body mass index either in healthy subjects or in ischemic stroke patients with or without diabetes both in males and females.