Serotonin2C receptor mRNA editing in neuropathic pain model

We investigated the effects on 5HT(serotonin) 2C receptor RNA editing efficiency of contusive SCI (spinal cord injury). Using cloning followed by sequence analysis on spinal cord samples taken, we compared mRNA editing. Our results might be evidence of a functional adaptation mechanism in which incr...

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Bibliographic Details
Published inNeuroscience research Vol. 60; no. 2; pp. 228 - 231
Main Authors Nakae, Aya, Nakai, Kunihiro, Tanaka, Tatsuya, Takashina, Masaki, Hagihira, Satoshi, Shibata, Masahiko, Ueda, Koichi, Mashimo, Takashi
Format Journal Article
LanguageEnglish
Published Ireland Elsevier Ireland Ltd 01.02.2008
Subjects
5HT2C receptor
Adaptation, Physiological - physiology
Allodynia
Animals
Behavior, Animal
Disease Models, Animal
Gene Expression Regulation - physiology
Male
Neuralgia - etiology
Neuropathic pain
Rats
Rats, Sprague-Dawley
Receptor, Serotonin, 5-HT2C - genetics
Receptor, Serotonin, 5-HT2C - metabolism
RNA editing
RNA Editing - physiology
RNA, Messenger - metabolism
Spinal Cord Injuries - complications
Spinal cord injury
Allodynia
RNA editing
Spinal cord injury
5HT2C receptor
Neuropathic pain
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Summary:We investigated the effects on 5HT(serotonin) 2C receptor RNA editing efficiency of contusive SCI (spinal cord injury). Using cloning followed by sequence analysis on spinal cord samples taken, we compared mRNA editing. Our results might be evidence of a functional adaptation mechanism in which increased expression of 5HT2C mRNA isoforms that encode receptors more sensitive to serotonin works to activate brainstem–spinal descending 5HT systems to, in effect, suppress transmission of nociceptive signals from primary afferent neurons to the spinal dorsal horn.
Bibliography:ObjectType-Article-1
SourceType-Scholarly Journals-1
ObjectType-Feature-2
content type line 23
ISSN:0168-0102
1872-8111
DOI:10.1016/j.neures.2007.10.004