Nanoemulgel: A Novel Nano Carrier as a Tool for Topical Drug Delivery

Nano-emulgel is an emerging drug delivery system intended to enhance the therapeutic profile of lipophilic drugs. Lipophilic formulations have a variety of limitations, which includes poor solubility, unpredictable absorption, and low oral bioavailability. Nano-emulgel, an amalgamated preparation of...

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Published inPharmaceutics Vol. 15; no. 1; p. 164
Main Authors Donthi, Mahipal Reddy, Munnangi, Siva Ram, Krishna, Kowthavarapu Venkata, Saha, Ranendra Narayan, Singhvi, Gautam, Dubey, Sunil Kumar
Format Journal Article
LanguageEnglish
Published Switzerland MDPI AG 03.01.2023
MDPI
Subjects
Bioavailability
Drug delivery systems
Drugs
Lipids
Metabolism
nano emulgel
Nanoparticles
Permeability
permeation
Pharmacokinetics
Review
Sedimentation & deposition
Skin
surfactant
topical delivery
Topical medication
Transdermal medication
Viscosity
topical delivery
bioavailability
nano emulgel
permeation
surfactant
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Summary:Nano-emulgel is an emerging drug delivery system intended to enhance the therapeutic profile of lipophilic drugs. Lipophilic formulations have a variety of limitations, which includes poor solubility, unpredictable absorption, and low oral bioavailability. Nano-emulgel, an amalgamated preparation of different systems aims to deal with these limitations. The novel system prepared by the incorporation of nano-emulsion into gel improves stability and enables drug delivery for both immediate and controlled release. The focus on nano-emulgel has also increased due to its ability to achieve targeted delivery, ease of application, absence of gastrointestinal degradation or the first pass metabolism, and safety profile. This review focuses on the formulation components of nano-emulgel for topical drug delivery, pharmacokinetics and safety profiles.
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These authors contributed equally to this work.
Current Affiliation: Department of Pharmaceutics and Drug Delivery, School of Pharmacy, The University of Mississippi, Oxford, MS 38677, USA.
Current Affiliation: R&D Healthcare Division Emami Ltd., 13, BT Road, Kolkata 700056, India.
Current Affiliation: Center for Pharmacometrics and Systems Pharmacology, Department of Pharmaceutics, College of Pharmacy, University of Florida, Orlando, FL 32827, USA.
ISSN:1999-4923
1999-4923
DOI:10.3390/pharmaceutics15010164