Genetics of ventral forebrain development and holoprosencephaly

The disease holoprosencephaly is the basis of the most common structural anomaly of the developing forebrain in humans. Numerous teratogens when administered during early gastrulation, have been associated with this condition. Recent studies have characterized molecules expressed in the prechordal p...

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Bibliographic Details
Published inCurrent Opinion in Genetics & Development Vol. 10; no. 3; pp. 262 - 269
Main Authors Muenke, Maximilian, Beachy, Philip A
Format Book Review Journal Article
LanguageEnglish
Published England Elsevier Ltd 01.06.2000
Subjects
Animals
Embryonic and Fetal Development
Holoprosencephaly
Holoprosencephaly - chemically induced
Holoprosencephaly - embryology
Holoprosencephaly - genetics
Humans
Morphogenesis
Patched
Prosencephalon - embryology
Signal Transduction
Smoothened
Sonic hedgehog
Teratogens
Sonic hedgehog
Neuroscience
Smoothened
Development
Genetics
Holoprosencephaly
Patched
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Summary:The disease holoprosencephaly is the basis of the most common structural anomaly of the developing forebrain in humans. Numerous teratogens when administered during early gastrulation, have been associated with this condition. Recent studies have characterized molecules expressed in the prechordal plate which are critical for normal brain formation. Perturbation of signaling pathways involving these molecules have been shown to cause holoprosencephaly in humans and other organisms.
Bibliography:ObjectType-Article-2
SourceType-Scholarly Journals-1
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ObjectType-Review-3
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ISSN:0959-437X
1879-0380
DOI:10.1016/S0959-437X(00)00084-8