Mechanisms involved in the Abacavir-mediated hypersensitivity syndrome
The potentially life-threatening adverse reactions to Abavacir （ABC）, a nucleoside analog reverse transcriptase inhibitor for the treatment of H1V infection, have been known for several years to be limited to individu- als expressing the HLA-B＊57：01 gene. Why the ABC hypersensitivity syn- drome is o...
Saved in:
| Published in | Cell research Vol. 22; no. 12; pp. 1637 - 1639 |
|---|---|
| Main Authors | , |
| Format | Journal Article |
| Language | English |
| Published |
London
Nature Publishing Group UK
01.12.2012
Nature Publishing Group |
| Subjects | |
| Online Access | Get full text |
| ISSN | 1001-0602 1748-7838 1748-7838 |
| DOI | 10.1038/cr.2012.105 |
Cover
| Abstract | The potentially life-threatening adverse reactions to Abavacir （ABC）, a nucleoside analog reverse transcriptase inhibitor for the treatment of H1V infection, have been known for several years to be limited to individu- als expressing the HLA-B＊57：01 gene. Why the ABC hypersensitivity syn- drome is only seen in HLA-B＊57：01- expressing subjects and what the precise mechanisms underlying this intolerance are remain however con- troversial. A series of recent studies, particularly a study by Illing et al. recently published in Nature, now answer some of these questions and offer new opportunities to better understand autoimmune disorders and prevent adverse reactions to other drugs. |
|---|---|
| AbstractList | The potentially life-threatening adverse reactions to Abavacir （ABC）, a nucleoside analog reverse transcriptase inhibitor for the treatment of H1V infection, have been known for several years to be limited to individu- als expressing the HLA-B＊57：01 gene. Why the ABC hypersensitivity syn- drome is only seen in HLA-B＊57：01- expressing subjects and what the precise mechanisms underlying this intolerance are remain however con- troversial. A series of recent studies, particularly a study by Illing et al. recently published in Nature, now answer some of these questions and offer new opportunities to better understand autoimmune disorders and prevent adverse reactions to other drugs. The potentially life-threatening adverse reactions to Abavacir (ABC), a nucleoside analog reverse transcriptase inhibitor for the treatment of HIV infection, have been known for several years to be limited to individuals expressing the HLA-B * 57:01 gene. Why the ABC hypersensitivity syndrome is only seen in HLA-B * 57:01-expressing subjects and what the precise mechanisms underlying this intolerance are remain however controversial. A series of recent studies, particularly a study by Illing et al . recently published in Nature , now answer some of these questions and offer new opportunities to better understand autoimmune disorders and prevent adverse reactions to other drugs. The potentially life-threatening adverse reactions to Abavacir (ABC), a nucleoside analog reverse transcriptase inhibitor for the treatment of HIV infection, have been known for several years to be limited to individuals expressing the HLA-B57:01 gene. Why the ABC hypersensitivity syndrome is only seen in HLA-B57:01-expressing subjects and what the precise mechanisms underlying this intolerance are remain however controversial. A series of recent studies, particularly a study by Illing et al. recently published in Nature, now answer some of these questions and offer new opportunities to better understand autoimmune disorders and prevent adverse reactions to other drugs.The potentially life-threatening adverse reactions to Abavacir (ABC), a nucleoside analog reverse transcriptase inhibitor for the treatment of HIV infection, have been known for several years to be limited to individuals expressing the HLA-B57:01 gene. Why the ABC hypersensitivity syndrome is only seen in HLA-B57:01-expressing subjects and what the precise mechanisms underlying this intolerance are remain however controversial. A series of recent studies, particularly a study by Illing et al. recently published in Nature, now answer some of these questions and offer new opportunities to better understand autoimmune disorders and prevent adverse reactions to other drugs. The potentially life-threatening adverse reactions to Abavacir (ABC), a nucleoside analog reverse transcriptase inhibitor for the treatment of HIV infection, have been known for several years to be limited to individuals expressing the HLA-B57:01 gene. Why the ABC hypersensitivity syndrome is only seen in HLA-B57:01-expressing subjects and what the precise mechanisms underlying this intolerance are remain however controversial. A series of recent studies, particularly a study by Illing et al. recently published in Nature, now answer some of these questions and offer new opportunities to better understand autoimmune disorders and prevent adverse reactions to other drugs. |
| Author | Anuska Llano Christian Brander |
| AuthorAffiliation | Irsicaixa AIDS Research Institute- HIVACAT, Hospital Universitari Germans Trias i Pujol, Badalona, Spain Universitat Autonoma de Barcelona, Hospital Universitari Germans Trias i Pujol, Badalona, Spain Institucio Catalana de Reserca i Estudis Avancats （ICREA） Barcelona, Spain |
| Author_xml | – sequence: 1 givenname: Anuska surname: Llano fullname: Llano, Anuska organization: Irsicaixa AIDS Research Institute – HIVACAT, Hospital Universitari Germans Trias i Pujol – sequence: 2 givenname: Christian surname: Brander fullname: Brander, Christian email: cbrander@irsicaixa.es organization: Irsicaixa AIDS Research Institute – HIVACAT, Hospital Universitari Germans Trias i Pujol, Universitat Autònoma de Barcelona, Hospital Universitari Germans Trias i Pujol, Institució Catalana de Reserca i Estudis Avançats (ICREA) |
| BackLink | https://www.ncbi.nlm.nih.gov/pubmed/22777424$$D View this record in MEDLINE/PubMed |
| BookMark | eNqNkU1rGzEQhkVJab566r249FJoN5nRx2r3EgihaQspubRnIWtlr8Ku5Ejygv99ZeyEJORQXTTDPPPyzswxOfDBW0I-IJwhsObcxDMKSEsi3pAjlLypZMOagxIDYAU10ENynNIdABVc4DtySKmUklN-RK5_W9Nr79KYZs5PYZhsV4JZ7u3scq6NnlysRts5nUuh36xsTNYnl93k8maWNr6LYbSn5O1CD8m-3_8n5O_19z9XP6ub2x-_ri5vKiNA5ErWNQW5kEZSpLWgjQXdzDuN3bzlVAIFziWTtelayTqDgiNFzmsLFjnjmp2Qi53uaj0vroz1OepBraIbddyooJ16XvGuV8swKSZQSN4WgS97gRju1zZlNbpk7DBob8M6KeR1WRGV7X-gtDwGbQMF_fwCvQvr6MsmthRiS9u2KdTHp-YfXT9cowC4A0wMKUW7UMZlnV3YzuIGhaC2F1cmqu3FSyJKz9cXPQ-yr9PfdnQqlF_a-MToq_invXgf_PK-dDyqc44coGbsH5O2w-Y |
| CitedBy_id | crossref_primary_10_4161_hv_21889 crossref_primary_10_1111_cea_14235 crossref_primary_10_1016_j_immbio_2012_12_001 crossref_primary_10_1111_1348_0421_12769 |
| Cites_doi | 10.1097/00130832-200208000-00003 10.1128/JVI.79.16.10218-10225.2005 10.1146/annurev-pharmtox-010611-134701 10.1038/nature11147 10.1097/QAD.0b013e328355fe8f 10.1073/pnas.1207934109 10.1016/j.immuni.2008.04.020 10.1016/j.jaci.2006.03.005 10.1016/j.jaci.2010.11.046 10.1002/eji.201142159 10.1016/j.it.2005.11.001 10.1007/s11882-002-0032-z 10.4049/jimmunol.158.4.1660 10.4049/jimmunol.157.3.1071 10.4049/jimmunol.155.1.462 10.4049/jimmunol.155.5.2670 |
| ContentType | Journal Article |
| Copyright | Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences 2012 Copyright Nature Publishing Group Dec 2012 Copyright © 2012 Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences 2012 Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences |
| Copyright_xml | – notice: Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences 2012 – notice: Copyright Nature Publishing Group Dec 2012 – notice: Copyright © 2012 Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences 2012 Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences |
| DBID | 2RA 92L CQIGP W94 WU4 ~WA AAYXX CITATION CGR CUY CVF ECM EIF NPM 3V. 7QO 7QP 7QR 7T5 7TK 7TM 7TO 7U9 7X7 7XB 88E 8FD 8FE 8FH 8FI 8FJ 8FK ABUWG AEUYN AFKRA AZQEC BBNVY BENPR BHPHI CCPQU DWQXO FR3 FYUFA GHDGH GNUQQ H94 HCIFZ K9. LK8 M0S M1P M7N M7P P64 PHGZM PHGZT PJZUB PKEHL PPXIY PQEST PQGLB PQQKQ PQUKI PRINS RC3 7X8 5PM |
| DOI | 10.1038/cr.2012.105 |
| DatabaseName | 维普期刊资源整合服务平台 中文科技期刊数据库-CALIS站点 中文科技期刊数据库-7.0平台 中文科技期刊数据库-自然科学 中文科技期刊数据库-自然科学-生物科学 中文科技期刊数据库- 镜像站点 CrossRef Medline MEDLINE MEDLINE (Ovid) MEDLINE MEDLINE PubMed ProQuest Central (Corporate) Biotechnology Research Abstracts Calcium & Calcified Tissue Abstracts Chemoreception Abstracts Immunology Abstracts Neurosciences Abstracts Nucleic Acids Abstracts Oncogenes and Growth Factors Abstracts Virology and AIDS Abstracts Health & Medical Collection (ProQuest) ProQuest Central (purchase pre-March 2016) Medical Database (Alumni Edition) Technology Research Database ProQuest SciTech Collection ProQuest Natural Science Collection Hospital Premium Collection Hospital Premium Collection (Alumni Edition) ProQuest Central (Alumni) (purchase pre-March 2016) ProQuest Central (Alumni) ProQuest One Sustainability ProQuest Central UK/Ireland ProQuest Central Essentials Biological Science Collection ProQuest Central Natural Science Collection ProQuest One ProQuest Central Korea Engineering Research Database Health Research Premium Collection Health Research Premium Collection (Alumni) ProQuest Central Student AIDS and Cancer Research Abstracts ProQuest SciTech Premium Collection ProQuest Health & Medical Complete (Alumni) Biological Sciences ProQuest Health & Medical Collection Medical Database Algology Mycology and Protozoology Abstracts (Microbiology C) Biological Science Database (ProQuest) Biotechnology and BioEngineering Abstracts ProQuest Central Premium ProQuest One Academic (New) ProQuest Health & Medical Research Collection ProQuest One Academic Middle East (New) ProQuest One Health & Nursing ProQuest One Academic Eastern Edition (DO NOT USE) ProQuest One Applied & Life Sciences ProQuest One Academic ProQuest One Academic UKI Edition ProQuest Central China Genetics Abstracts MEDLINE - Academic PubMed Central (Full Participant titles) |
| DatabaseTitle | CrossRef MEDLINE Medline Complete MEDLINE with Full Text PubMed MEDLINE (Ovid) ProQuest Central Student Oncogenes and Growth Factors Abstracts ProQuest Central Essentials Nucleic Acids Abstracts SciTech Premium Collection ProQuest Central China ProQuest One Applied & Life Sciences ProQuest One Sustainability Health Research Premium Collection Natural Science Collection Health & Medical Research Collection Biological Science Collection Chemoreception Abstracts ProQuest Central (New) ProQuest Medical Library (Alumni) Virology and AIDS Abstracts ProQuest Biological Science Collection ProQuest One Academic Eastern Edition ProQuest Hospital Collection Health Research Premium Collection (Alumni) Biological Science Database Neurosciences Abstracts ProQuest Hospital Collection (Alumni) Biotechnology and BioEngineering Abstracts ProQuest Health & Medical Complete ProQuest One Academic UKI Edition Engineering Research Database ProQuest One Academic Calcium & Calcified Tissue Abstracts ProQuest One Academic (New) Technology Research Database ProQuest One Academic Middle East (New) ProQuest Health & Medical Complete (Alumni) ProQuest Central (Alumni Edition) ProQuest One Community College ProQuest One Health & Nursing ProQuest Natural Science Collection ProQuest Central ProQuest Health & Medical Research Collection Genetics Abstracts Biotechnology Research Abstracts Health and Medicine Complete (Alumni Edition) ProQuest Central Korea Algology Mycology and Protozoology Abstracts (Microbiology C) AIDS and Cancer Research Abstracts ProQuest SciTech Collection ProQuest Medical Library Immunology Abstracts ProQuest Central (Alumni) MEDLINE - Academic |
| DatabaseTitleList | MEDLINE - Academic MEDLINE AIDS and Cancer Research Abstracts ProQuest Central Student |
| Database_xml | – sequence: 1 dbid: NPM name: PubMed url: https://proxy.k.utb.cz/login?url=http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=PubMed sourceTypes: Index Database – sequence: 2 dbid: EIF name: MEDLINE url: https://proxy.k.utb.cz/login?url=https://www.webofscience.com/wos/medline/basic-search sourceTypes: Index Database – sequence: 3 dbid: BENPR name: ProQuest Central Database Suite (ProQuest) url: https://www.proquest.com/central sourceTypes: Aggregation Database |
| DeliveryMethod | fulltext_linktorsrc |
| Discipline | Biology |
| DocumentTitleAlternate | Mechanisms involved in the Abacavir-mediated hypersensitivity syndrome |
| EISSN | 1748-7838 |
| EndPage | 1639 |
| ExternalDocumentID | PMC3515749 2830351751 22777424 10_1038_cr_2012_105 44140063 |
| Genre | Journal Article |
| GroupedDBID | --- -01 -0A -Q- -SA -S~ 0R~ 29B 2B. 2C. 2RA 2WC 36B 39C 3V. 4.4 406 53G 5GY 5VR 5XA 5XB 5XL 6J9 70F 7X7 88E 8FE 8FH 8FI 8FJ 92E 92I 92L 92M 92Q 93N 9D9 9DA AADWK AANZL AATNV AAWBL AAYFA AAYJO AAZLF ABAWZ ABGIJ ABJNI ABUWG ACAOD ACBMV ACBRV ACBYP ACGFO ACGFS ACIGE ACIWK ACKTT ACPRK ACRQY ACTTH ACVWB ACZOJ ADBBV ADFRT ADHDB ADMDM ADQMX ADYYL AEDAW AEFTE AEJRE AENEX AESKC AEVLU AEXYK AFKRA AFNRJ AFRAH AFSHS AFUIB AGEZK AGGBP AGHAI AHMBA AHSBF AILAN AJCLW AJDOV AJRNO ALFFA ALMA_UNASSIGNED_HOLDINGS AMRJV AMYLF AOIJS AXYYD BAWUL BBNVY BENPR BHPHI BKKNO BPHCQ BVXVI C1A CAG CAJEA CAJUS CCEZO CCPQU CCVFK CHBEP COF CQIGP CS3 CW9 DIK DNIVK DPUIP DU5 E3Z EBLON EBS EE. EIOEI EJD EMB EMOBN F5P FA0 FDQFY FERAY FIZPM FSGXE FYUFA GX1 HCIFZ HMCUK HYE HZ~ IWAJR JSO JUIAU JZLTJ KQ8 LK8 M1P M7P NAO NQJWS NXXTH NYICJ O9- OK1 P2P PQQKQ PROAC PSQYO Q-- Q-0 R-A RNS RNT RNTTT RPM RT1 S.. SNX SNYQT SOHCF SRMVM SV3 SWTZT T8Q TAOOD TBHMF TCJ TDRGL TGP TR2 U1F U1G U5A U5K UKHRP W94 WFFXF WU4 XSB ~88 ~WA AACDK AAHBH AASML AAXDM AAYZH ABAKF ABZZP ACMJI AEFQL AEMSY AEUYN AFBBN AGQEE AIGIU ALIPV FIGPU LGEZI LOTEE NADUK ROL SOJ AAYXX ABBRH ABDBE ABFSG ACMFV ACSTC AEZWR AFDZB AFHIU AHWEU AIXLP ATHPR AYFIA CITATION PHGZM PHGZT CGR CUY CVF ECM EIF NPM 7QO 7QP 7QR 7T5 7TK 7TM 7TO 7U9 7XB 8FD 8FK ABRTQ AZQEC DWQXO FR3 GNUQQ H94 K9. M7N P64 PJZUB PKEHL PPXIY PQEST PQGLB PQUKI PRINS RC3 7X8 PUEGO 5PM |
| ID | FETCH-LOGICAL-c505t-766207f7c72126528e0a8bda1db9427020447376cd973dc154121446e0e1434a3 |
| IEDL.DBID | 7X7 |
| ISSN | 1001-0602 1748-7838 |
| IngestDate | Thu Aug 21 14:02:35 EDT 2025 Thu Sep 04 18:48:11 EDT 2025 Fri Sep 05 12:45:39 EDT 2025 Fri Jul 25 09:02:51 EDT 2025 Wed Feb 19 01:51:42 EST 2025 Thu Apr 24 23:04:00 EDT 2025 Tue Jul 01 03:41:30 EDT 2025 Fri Feb 21 02:38:11 EST 2025 Wed Feb 14 10:43:58 EST 2024 |
| IsDoiOpenAccess | false |
| IsOpenAccess | true |
| IsPeerReviewed | true |
| IsScholarly | true |
| Issue | 12 |
| Language | English |
| License | http://www.springer.com/tdm |
| LinkModel | DirectLink |
| MergedId | FETCHMERGED-LOGICAL-c505t-766207f7c72126528e0a8bda1db9427020447376cd973dc154121446e0e1434a3 |
| Notes | The potentially life-threatening adverse reactions to Abavacir （ABC）, a nucleoside analog reverse transcriptase inhibitor for the treatment of H1V infection, have been known for several years to be limited to individu- als expressing the HLA-B＊57：01 gene. Why the ABC hypersensitivity syn- drome is only seen in HLA-B＊57：01- expressing subjects and what the precise mechanisms underlying this intolerance are remain however con- troversial. A series of recent studies, particularly a study by Illing et al. recently published in Nature, now answer some of these questions and offer new opportunities to better understand autoimmune disorders and prevent adverse reactions to other drugs. 31-1568/Q ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 content type line 14 content type line 23 ObjectType-Article-2 ObjectType-Feature-1 |
| OpenAccessLink | https://www.nature.com/articles/cr2012105.pdf |
| PMID | 22777424 |
| PQID | 1221192998 |
| PQPubID | 536307 |
| PageCount | 3 |
| ParticipantIDs | pubmedcentral_primary_oai_pubmedcentral_nih_gov_3515749 proquest_miscellaneous_1464512799 proquest_miscellaneous_1222230980 proquest_journals_1221192998 pubmed_primary_22777424 crossref_citationtrail_10_1038_cr_2012_105 crossref_primary_10_1038_cr_2012_105 springer_journals_10_1038_cr_2012_105 chongqing_primary_44140063 |
| ProviderPackageCode | CITATION AAYXX |
| PublicationCentury | 2000 |
| PublicationDate | 2012-12-01 |
| PublicationDateYYYYMMDD | 2012-12-01 |
| PublicationDate_xml | – month: 12 year: 2012 text: 2012-12-01 day: 01 |
| PublicationDecade | 2010 |
| PublicationPlace | London |
| PublicationPlace_xml | – name: London – name: England |
| PublicationTitle | Cell research |
| PublicationTitleAbbrev | Cell Res |
| PublicationTitleAlternate | Cell Research |
| PublicationYear | 2012 |
| Publisher | Nature Publishing Group UK Nature Publishing Group |
| Publisher_xml | – name: Nature Publishing Group UK – name: Nature Publishing Group |
| References | Chessman, Kostenko, Lethborg (CR5) 2008; 28 Barber, Percival, Arnett, Gumperz, Chen, Parham (CR9) 1997; 158 Adam, Eriksson, Schnyder, Fontana, Pichler, Yerly (CR11) 2012; 42 Bharadwaj, Illing, Theodossis, Purcell, Rossjohn, McCluskey (CR1) 2012; 52 Wu, Sanderson, Farrell (CR4) 2006; 118 Mauri-Hellweg, Zanni, Frei (CR15) 1996; 157 Norcross, Luo, Lu (CR7) 2012; 26 Brander, Mauri-Hellweg, Bettens, Rolli, Goldman, Pichler (CR14) 1995; 155 Pichler (CR2) 2002; 2 Phillips, Chung, Mockenhaupt, Roujeau, Mallal (CR13) 2011; 127 Illing, Vivian, Dudek (CR6) 2012; 486 Ostrov, Grant, Pompeu (CR8) 2012; 109 Mauri-Hellweg, Bettens, Mauri, Brander, Hunziker, Pichler (CR16) 1995; 155 Burrows, Rossjohn, McCluskey (CR12) 2006; 27 Frahm, Adams, Kiepiela (CR10) 2005; 79 Pichler (CR3) 2002; 2 Y Wu (BFcr2012105_CR4) 2006; 118 SR Burrows (BFcr2012105_CR12) 2006; 27 C Brander (BFcr2012105_CR14) 1995; 155 LD Barber (BFcr2012105_CR9) 1997; 158 N Frahm (BFcr2012105_CR10) 2005; 79 PT Illing (BFcr2012105_CR6) 2012; 486 D Mauri-Hellweg (BFcr2012105_CR16) 1995; 155 DA Ostrov (BFcr2012105_CR8) 2012; 109 WJ Pichler (BFcr2012105_CR2) 2002; 2 MA Norcross (BFcr2012105_CR7) 2012; 26 D Mauri-Hellweg (BFcr2012105_CR15) 1996; 157 EJ Phillips (BFcr2012105_CR13) 2011; 127 M Bharadwaj (BFcr2012105_CR1) 2012; 52 D Chessman (BFcr2012105_CR5) 2008; 28 J Adam (BFcr2012105_CR11) 2012; 42 WJ Pichler (BFcr2012105_CR3) 2002; 2 22585534 - Eur J Immunol. 2012 Jul;42(7):1706-16 7602118 - J Immunol. 1995 Jul 1;155(1):462-72 22017685 - Annu Rev Pharmacol Toxicol. 2012;52:401-31 12130944 - Curr Opin Allergy Clin Immunol. 2002 Aug;2(4):301-5 16297661 - Trends Immunol. 2006 Jan;27(1):11-6 21354501 - J Allergy Clin Immunol. 2011 Mar;127(3 Suppl):S60-6 22645359 - Proc Natl Acad Sci U S A. 2012 Jun 19;109(25):9959-64 8757611 - J Immunol. 1996 Aug 1;157(3):1071-9 22617051 - AIDS. 2012 Jul 17;26(11):F21-9 11895620 - Curr Allergy Asthma Rep. 2002 Jan;2(1):9-15 16815161 - J Allergy Clin Immunol. 2006 Jul;118(1):233-41 16051815 - J Virol. 2005 Aug;79(16):10218-25 22722860 - Nature. 2012 Jun 28;486(7404):554-8 7650395 - J Immunol. 1995 Sep 1;155(5):2670-8 9029102 - J Immunol. 1997 Feb 15;158(4):1660-9 18549801 - Immunity. 2008 Jun;28(6):822-32 |
| References_xml | – volume: 2 start-page: 301 year: 2002 end-page: 305 ident: CR2 article-title: Pharmacological interaction of drugs with antigen-specific immune receptors: the p-i concept publication-title: Curr Opin Allergy Clin Immunol doi: 10.1097/00130832-200208000-00003 – volume: 79 start-page: 10218 year: 2005 end-page: 10225 ident: CR10 article-title: HLA-B63 presents HLA-B57/B58-restricted cytotoxic T-lymphocyte epitopes and is associated with low human immunodeficiency virus load publication-title: J Virol doi: 10.1128/JVI.79.16.10218-10225.2005 – volume: 52 start-page: 401 year: 2012 end-page: 431 ident: CR1 article-title: Drug hypersensitivity and human leukocyte antigens of the major histocompatibility complex publication-title: Annu Rev Pharmacol Toxicol doi: 10.1146/annurev-pharmtox-010611-134701 – volume: 486 start-page: 554 year: 2012 end-page: 558 ident: CR6 article-title: Immune self-reactivity triggered by drug-modified HLA-peptide repertoire publication-title: Nature doi: 10.1038/nature11147 – volume: 155 start-page: 2670 year: 1995 end-page: 2678 ident: CR14 article-title: Heterogeneous T cell responses to beta-lactam-modified self-structures are observed in penicillin-allergic individuals publication-title: J Immunol – volume: 155 start-page: 462 year: 1995 end-page: 472 ident: CR16 article-title: Activation of drug-specific CD4+ and CD8+ T cells in individuals allergic to sulfonamides, phenytoin, and carbamazepine publication-title: J Immunol – volume: 26 start-page: F21 year: 2012 end-page: F29 ident: CR7 article-title: Abacavir induces loading of novel self-peptides into HLA-B 57: 01: an autoimmune model for HLA-associated drug hypersensitivity publication-title: AIDS doi: 10.1097/QAD.0b013e328355fe8f – volume: 109 start-page: 9959 year: 2012 end-page: 9964 ident: CR8 article-title: Drug hypersensitivity caused by alteration of the MHC-presented self-peptide repertoire publication-title: Proc Natl Acad Sci USA doi: 10.1073/pnas.1207934109 – volume: 28 start-page: 822 year: 2008 end-page: 832 ident: CR5 article-title: Human leukocyte antigen class I-restricted activation of CD8+ T cells provides the immunogenetic basis of a systemic drug hypersensitivity publication-title: Immunity doi: 10.1016/j.immuni.2008.04.020 – volume: 158 start-page: 1660 year: 1997 end-page: 1669 ident: CR9 article-title: Polymorphism in the alpha 1 helix of the HLA-B heavy chain can have an overriding influence on peptide-binding specificity publication-title: J Immunol – volume: 118 start-page: 233 year: 2006 end-page: 241 ident: CR4 article-title: Activation of T cells by carbamazepine and carbamazepine metabolites publication-title: J Allergy Clin Immunol doi: 10.1016/j.jaci.2006.03.005 – volume: 127 start-page: S60 year: 2011 end-page: S66 ident: CR13 article-title: Drug hypersensitivity: pharmacogenetics and clinical syndromes publication-title: J Allergy Clin Immunol doi: 10.1016/j.jaci.2010.11.046 – volume: 157 start-page: 1071 year: 1996 end-page: 1079 ident: CR15 article-title: Cross-reactivity of T cell lines and clones to beta-lactam antibiotics publication-title: J Immunol – volume: 42 start-page: 1706 year: 2012 end-page: 1716 ident: CR11 article-title: Avidity determines T-cell reactivity in abacavir hypersensitivity publication-title: Eur J Immunol doi: 10.1002/eji.201142159 – volume: 27 start-page: 11 year: 2006 end-page: 16 ident: CR12 article-title: Have we cut ourselves too short in mapping CTL epitopes? publication-title: Trends Immunol doi: 10.1016/j.it.2005.11.001 – volume: 2 start-page: 9 year: 2002 end-page: 15 ident: CR3 article-title: T cells in drug allergy publication-title: Curr Allergy Asthma Rep doi: 10.1007/s11882-002-0032-z – volume: 27 start-page: 11 year: 2006 ident: BFcr2012105_CR12 publication-title: Trends Immunol doi: 10.1016/j.it.2005.11.001 – volume: 158 start-page: 1660 year: 1997 ident: BFcr2012105_CR9 publication-title: J Immunol doi: 10.4049/jimmunol.158.4.1660 – volume: 118 start-page: 233 year: 2006 ident: BFcr2012105_CR4 publication-title: J Allergy Clin Immunol doi: 10.1016/j.jaci.2006.03.005 – volume: 42 start-page: 1706 year: 2012 ident: BFcr2012105_CR11 publication-title: Eur J Immunol doi: 10.1002/eji.201142159 – volume: 26 start-page: F21 year: 2012 ident: BFcr2012105_CR7 publication-title: AIDS doi: 10.1097/QAD.0b013e328355fe8f – volume: 109 start-page: 9959 year: 2012 ident: BFcr2012105_CR8 publication-title: Proc Natl Acad Sci USA doi: 10.1073/pnas.1207934109 – volume: 79 start-page: 10218 year: 2005 ident: BFcr2012105_CR10 publication-title: J Virol doi: 10.1128/JVI.79.16.10218-10225.2005 – volume: 157 start-page: 1071 year: 1996 ident: BFcr2012105_CR15 publication-title: J Immunol doi: 10.4049/jimmunol.157.3.1071 – volume: 2 start-page: 9 year: 2002 ident: BFcr2012105_CR3 publication-title: Curr Allergy Asthma Rep doi: 10.1007/s11882-002-0032-z – volume: 486 start-page: 554 year: 2012 ident: BFcr2012105_CR6 publication-title: Nature doi: 10.1038/nature11147 – volume: 52 start-page: 401 year: 2012 ident: BFcr2012105_CR1 publication-title: Annu Rev Pharmacol Toxicol doi: 10.1146/annurev-pharmtox-010611-134701 – volume: 28 start-page: 822 year: 2008 ident: BFcr2012105_CR5 publication-title: Immunity doi: 10.1016/j.immuni.2008.04.020 – volume: 2 start-page: 301 year: 2002 ident: BFcr2012105_CR2 publication-title: Curr Opin Allergy Clin Immunol doi: 10.1097/00130832-200208000-00003 – volume: 155 start-page: 462 year: 1995 ident: BFcr2012105_CR16 publication-title: J Immunol doi: 10.4049/jimmunol.155.1.462 – volume: 127 start-page: S60 year: 2011 ident: BFcr2012105_CR13 publication-title: J Allergy Clin Immunol doi: 10.1016/j.jaci.2010.11.046 – volume: 155 start-page: 2670 year: 1995 ident: BFcr2012105_CR14 publication-title: J Immunol doi: 10.4049/jimmunol.155.5.2670 – reference: 18549801 - Immunity. 2008 Jun;28(6):822-32 – reference: 7602118 - J Immunol. 1995 Jul 1;155(1):462-72 – reference: 11895620 - Curr Allergy Asthma Rep. 2002 Jan;2(1):9-15 – reference: 12130944 - Curr Opin Allergy Clin Immunol. 2002 Aug;2(4):301-5 – reference: 16051815 - J Virol. 2005 Aug;79(16):10218-25 – reference: 16815161 - J Allergy Clin Immunol. 2006 Jul;118(1):233-41 – reference: 9029102 - J Immunol. 1997 Feb 15;158(4):1660-9 – reference: 16297661 - Trends Immunol. 2006 Jan;27(1):11-6 – reference: 7650395 - J Immunol. 1995 Sep 1;155(5):2670-8 – reference: 22645359 - Proc Natl Acad Sci U S A. 2012 Jun 19;109(25):9959-64 – reference: 8757611 - J Immunol. 1996 Aug 1;157(3):1071-9 – reference: 22585534 - Eur J Immunol. 2012 Jul;42(7):1706-16 – reference: 21354501 - J Allergy Clin Immunol. 2011 Mar;127(3 Suppl):S60-6 – reference: 22017685 - Annu Rev Pharmacol Toxicol. 2012;52:401-31 – reference: 22617051 - AIDS. 2012 Jul 17;26(11):F21-9 – reference: 22722860 - Nature. 2012 Jun 28;486(7404):554-8 |
| SSID | ssj0025451 |
| Score | 2.0664718 |
| Snippet | The potentially life-threatening adverse reactions to Abavacir （ABC）, a nucleoside analog reverse transcriptase inhibitor for the treatment of H1V infection,... The potentially life-threatening adverse reactions to Abavacir (ABC), a nucleoside analog reverse transcriptase inhibitor for the treatment of HIV infection,... |
| SourceID | pubmedcentral proquest pubmed crossref springer chongqing |
| SourceType | Open Access Repository Aggregation Database Index Database Enrichment Source Publisher |
| StartPage | 1637 |
| SubjectTerms | 631/250/249/1313 631/80/304 692/700/565/2194 Alleles Anti-HIV Agents - adverse effects Anti-HIV Agents - pharmacology Anti-HIV Agents - therapeutic use Autoimmune diseases Autoimmunity - drug effects Autoimmunity - immunology Biomedical and Life Sciences Carbamazepine - pharmacology Cell Biology Dideoxynucleosides - adverse effects Dideoxynucleosides - pharmacology Dideoxynucleosides - therapeutic use Drug Hypersensitivity - etiology Drug Hypersensitivity - genetics Drug Hypersensitivity - immunology HIV Infections - drug therapy HIV Infections - immunology HIV Infections - metabolism HLA-B HLA-B Antigens - genetics HLA-B Antigens - metabolism Human immunodeficiency virus Humans Hypersensitivity Life Sciences Research Highlight Side effects Syndrome 不良反应 介导 机制 核苷类似物 综合征 自身免疫性疾病 超敏反应 |
| Title | Mechanisms involved in the Abacavir-mediated hypersensitivity syndrome |
| URI | http://lib.cqvip.com/qk/85240X/201212/44140063.html https://link.springer.com/article/10.1038/cr.2012.105 https://www.ncbi.nlm.nih.gov/pubmed/22777424 https://www.proquest.com/docview/1221192998 https://www.proquest.com/docview/1222230980 https://www.proquest.com/docview/1464512799 https://pubmed.ncbi.nlm.nih.gov/PMC3515749 |
| Volume | 22 |
| hasFullText | 1 |
| inHoldings | 1 |
| isFullTextHit | |
| isPrint | |
| link | http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwfV3daxQxEB-0RfBFtH5trWWF-iKEZrPZZPdJqvQogkXEwr0t-TrvoO61t9eC_70z2Y96nvRtlwwhH5PJL5nJbwCOrOezzM5yprgRTDphWSWNYorgq6wC6QlFW5yrswv5ZVpM-wu3tg-rHGxiNNR-6eiO_DgTxEWGxrP8eHXNKGsUeVf7FBoPYTdSl6E-6-ndgQvRQTxwxbAhRZE8e90z8_LYERdoJijNLbEqzJfNz2vcKzZ3py3IuR05-Y_7NO5Kk6fwpIeT6Uk3_8_gQWj24FGXYPL3c5h8DfSyd9H-atNFg5boNnj8SBH1pSfWOHO7WLH4eASBZzrHM-mqpYj2LqVEOtAZvICLyemPz2esz5zAHCKaNdNKCa5n2uH5TqhClIGb0nqTeVtJeoHGpdRoWpyvdO4dwqgsUqcFHhA_SZO_hJ1m2YTXkFqjM8cr7ou8kFbkVrsyeD0LBsGSU2UC--Po1VcdQ0aNGEsS-EngwzCctes5xyn1xWUdfd95WbtVTfOAP0UCR6PwUNF_xQ6Gean79dbWd9qRwLuxGFcKuT9ME5Y3UQaxEK9Kfo8MOXozoasqgVfdVI9tEUIjVhYyAb2hBKMAMXVvljSLeWTszhE1aol1vh_U5a-mb3dx__4uvoHHJNkF1RzAznp1E94iNFrbw6j_h7D76fT82_c_8EsMrw |
| linkProvider | ProQuest |
| linkToHtml | http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwtV3fb9MwED6NTgheJhgwMgYEaXtBiuY4jp08IDRgVce2CqFN2luwHZdWYunWdEP7p_gbucsvKEV721uiXK3EvrO_6919B7BtcjYKzSgKJNM8EJabIBVaBpLgq0gd6QllWwzl4FR8PovPVuBXWwtDaZXtnlht1PnU0n_kuyEnLjLcPJP3F5cBdY2i6GrbQqNWi0N38xNdtvLdwSdc3x3O-_snHwdB01UgsHjazwMlJWdqpCz6PlzGPHFMJybXYW5SQdVZTAiFZmfzVEW5RYgRVrRijjnEFkJHOO49WBVU0dqD1Q_7wy9fOxcP8Ujl4lWJSpJyh9brwvZk1xL7aMipsS7xOIynxfdLPJ0Wz8MlkLucq_lPwLY6B_uPYK0BsP5erXGPYcUV63C_bml58wT6x45qiSfleelPCtz7rl2OFz7iTH_PaKuvJ7OgKldBqOuP0QuelZRDXzex8FsChadweiez-gx6xbRwz8E3WoWWpSyPo1gYHhllE5erkdMIz6xMPNjsZi-7qDk5MkR1guCWB2_b6cxsw3JOzTZ-ZFW0PUoyO8toHfAm9mC7E24H-q_YVrsuWWPhZfZHHz140z1G26SAiy7c9KqSQfTF0oTdIkOh5ZCrNPVgo17q7l04V4jOufBALShBJ0Dc4ItPism44giPEKcqgWPutOry16svf-Lm7Z_4Gh4MTo6PsqOD4eELeEi_qlN6tqA3n125lwjM5uZVYw0-fLtrA_wNaPlGBA |
| linkToPdf | http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwtV3dT9RAEJ8gRsOLQfwqgtYEXkya22633fbBEAJeQJT4IMm91d3t1rtEenA9MPxr_nXObD_wPMMbb206t2l3Z3Z_czPzG4AdXbAy1GUUJEzxQBiug0yoJEgIvorMkp5QtsVpcnQmPo3i0Qr87mphKK2y2xPdRl1MDf1HPgg5cZHh5pkOyjYt4uvhcO_iMqAOUhRp7dppNCpyYm9-oftWfzg-xLXe5Xz48dvBUdB2GAgMnvzzQCYJZ7KUBv0gnsQ8tUylulBhoTNBlVpMCIkmaIpMRoVBuBE6ijHLLOIMoSIc9wE8lBGiKrQlObp19hCZOGfPpSwllEW00ZS4pwNDPKQhpxa7xOgwnlY_LvGcWjwZl-DuctbmP6FbdyIO1-FJC2X9_Ub3nsKKrTbgUdPc8uYZDL9Yqiqe1Oe1P6lwF7y2BV74iDj9fa2Mup7MAle4gqDXH6M_PKspm75pZ-F3VArP4exe5vQFrFbTyr4CXysZGpaxIo5ioXmkpUltIUurEKiZJPVgs5-9_KJh58gR3wkCXh6876YzNy3fObXd-Jm7uHuU5maW0zrgTezBTi_cDfRfsa1uXfLW1uv8VjM9eNc_Riul0Iuq7PTKySAOY1nK7pChIHPIZZZ58LJZ6v5dOJeI07nwQC4oQS9ALOGLT6rJ2LGFR4hYpcAxdzt1-evVlz9x8-5PfAuP0ezyz8enJ69hjX7U5PZswep8dmW3EaHN9RtnCj58v2_b-wMRS0jL |
| openUrl | ctx_ver=Z39.88-2004&ctx_enc=info%3Aofi%2Fenc%3AUTF-8&rfr_id=info%3Asid%2Fsummon.serialssolutions.com&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rft.genre=article&rft.atitle=Mechanisms+involved+in+the+Abacavir-mediated+hypersensitivity+syndrome&rft.jtitle=Cell+research&rft.au=Llano%2C+Anuska&rft.au=Brander%2C+Christian&rft.date=2012-12-01&rft.pub=Nature+Publishing+Group&rft.issn=1001-0602&rft.eissn=1748-7838&rft.volume=22&rft.issue=12&rft.spage=1637&rft.epage=1639&rft_id=info:doi/10.1038%2Fcr.2012.105&rft_id=info%3Apmid%2F22777424&rft.externalDocID=PMC3515749 |
| thumbnail_s | http://utb.summon.serialssolutions.com/2.0.0/image/custom?url=http%3A%2F%2Fimage.cqvip.com%2Fvip1000%2Fqk%2F85240X%2F85240X.jpg |