Mechanisms involved in the Abacavir-mediated hypersensitivity syndrome

The potentially life-threatening adverse reactions to Abavacir （ABC）, a nucleoside analog reverse transcriptase inhibitor for the treatment of H1V infection, have been known for several years to be limited to individu- als expressing the HLA-B＊57：01 gene. Why the ABC hypersensitivity syn- drome is o...

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Bibliographic Details
Published in	Cell research Vol. 22; no. 12; pp. 1637 - 1639
Main Authors	Llano, Anuska, Brander, Christian
Format	Journal Article
Language	English
Published	London Nature Publishing Group UK 01.12.2012 Nature Publishing Group
Subjects	631/250/249/1313 631/80/304 692/700/565/2194 Alleles Anti-HIV Agents - adverse effects Anti-HIV Agents - pharmacology Anti-HIV Agents - therapeutic use Autoimmune diseases Autoimmunity - drug effects Autoimmunity - immunology Biomedical and Life Sciences Carbamazepine - pharmacology Cell Biology Dideoxynucleosides - adverse effects Dideoxynucleosides - pharmacology Dideoxynucleosides - therapeutic use Drug Hypersensitivity - etiology Drug Hypersensitivity - genetics Drug Hypersensitivity - immunology HIV Infections - drug therapy HIV Infections - immunology HIV Infections - metabolism HLA-B HLA-B Antigens - genetics HLA-B Antigens - metabolism Human immunodeficiency virus Humans Hypersensitivity Life Sciences Research Highlight Side effects Syndrome 不良反应介导机制核苷类似物综合征自身免疫性疾病超敏反应
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ISSN	1001-0602 1748-7838 1748-7838
DOI	10.1038/cr.2012.105

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Summary:	The potentially life-threatening adverse reactions to Abavacir （ABC）, a nucleoside analog reverse transcriptase inhibitor for the treatment of H1V infection, have been known for several years to be limited to individu- als expressing the HLA-B＊57：01 gene. Why the ABC hypersensitivity syn- drome is only seen in HLA-B＊57：01- expressing subjects and what the precise mechanisms underlying this intolerance are remain however con- troversial. A series of recent studies, particularly a study by Illing et al. recently published in Nature, now answer some of these questions and offer new opportunities to better understand autoimmune disorders and prevent adverse reactions to other drugs.
Bibliography:	The potentially life-threatening adverse reactions to Abavacir （ABC）, a nucleoside analog reverse transcriptase inhibitor for the treatment of H1V infection, have been known for several years to be limited to individu- als expressing the HLA-B＊57：01 gene. Why the ABC hypersensitivity syn- drome is only seen in HLA-B＊57：01- expressing subjects and what the precise mechanisms underlying this intolerance are remain however con- troversial. A series of recent studies, particularly a study by Illing et al. recently published in Nature, now answer some of these questions and offer new opportunities to better understand autoimmune disorders and prevent adverse reactions to other drugs. 31-1568/Q ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 content type line 14 content type line 23 ObjectType-Article-2 ObjectType-Feature-1
ISSN:	1001-0602 1748-7838 1748-7838
DOI:	10.1038/cr.2012.105