Clinical Effects of the Extract of the Seeds of the Indian Celery—Apium graveolens—In Horses Affected by Chronic Osteoarthritis

The extract of the seeds from Indian celery, Apium greaveolens (CSE), tested in experimental animals (rodents), and in humans affected by chronic osteoarthritic diseases, exhibits anti-inflammatory effects that can be compared, to some degree, to those of non-steroid anti-inflammatory drugs (NSAID)....

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Published in	Animals (Basel) Vol. 9; no. 8; p. 585
Main Authors	Battaglia, Beatrice, Angelone, Mario, Vera, Elena, Basini, Giuseppina, Bussolati, Simona, Paci, Massimiliano, Del Bue, Maurizio, Aldigeri, Raffaella, Grolli, Stefano, Quintavalla, Fausto, Ramoni, Roberto
Format	Journal Article
Language	English
Published	Switzerland MDPI AG 20.08.2019 MDPI
Subjects	analgesic effect anti-inflammatory activity anti-inflammatory agents Apium graveolens Arthritis blood sampling celery chronic orthopedic disorders dosage Drug dosages exhibitions Horses humans laboratory animals natural extract NSAID orthopedics osteoarthritis Pain phytotherapy rodents seeds apium graveolens natural extract NSAID osteoarthritis phytotherapy chronic orthopedic disorders
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Abstract	The extract of the seeds from Indian celery, Apium greaveolens (CSE), tested in experimental animals (rodents), and in humans affected by chronic osteoarthritic diseases, exhibits anti-inflammatory effects that can be compared, to some degree, to those of non-steroid anti-inflammatory drugs (NSAID). In view of a potential use of CSE in the equine species, it was tested on horses affected by chronic articular pathologies. The trial was performed on 20 horses divided into three different groups, orally treated with 0 (controls), 7.0 or 30 g of CSE BID. Basic orthopedic examinations were conducted, vital signs were observed, and blood samples collected. Improvement was observed at the highest dosage tested (30 g of CSE BID), as reflected in the score values of three clinical parameters, (i) amplitude and (ii) sensitivity to passive flexion and (iii) flexion test. Since the improvement of these parameters can be correlated with a lower perception of the pain, the present data suggest that the CSE treatment can have an analgesic effect in horses affected by chronic osteoarthritic diseases.
AbstractList	The extract of the seeds from Indian celery, Apium greaveolens (CSE), tested in experimental animals (rodents), and in humans affected by chronic osteoarthritic diseases, exhibits anti-inflammatory effects that can be compared, to some degree, to those of non-steroid anti-inflammatory drugs (NSAID). In view of a potential use of CSE in the equine species, it was tested on horses affected by chronic articular pathologies. The trial was performed on 20 horses divided into three different groups, orally treated with 0 (controls), 7.0 or 30 g of CSE BID. Basic orthopedic examinations were conducted, vital signs were observed, and blood samples collected. Improvement was observed at the highest dosage tested (30 g of CSE BID), as reflected in the score values of three clinical parameters, (i) amplitude and (ii) sensitivity to passive flexion and (iii) flexion test. Since the improvement of these parameters can be correlated with a lower perception of the pain, the present data suggest that the CSE treatment can have an analgesic effect in horses affected by chronic osteoarthritic diseases. The extract of the seeds from Indian celery, (CSE), tested in experimental animals (rodents), and in humans affected by chronic osteoarthritic diseases, exhibits anti-inflammatory effects that can be compared, to some degree, to those of non-steroid anti-inflammatory drugs (NSAID). In view of a potential use of CSE in the equine species, it was tested on horses affected by chronic articular pathologies. The trial was performed on 20 horses divided into three different groups, orally treated with 0 (controls), 7.0 or 30 g of CSE BID. Basic orthopedic examinations were conducted, vital signs were observed, and blood samples collected. Improvement was observed at the highest dosage tested (30 g of CSE BID), as reflected in the score values of three clinical parameters, (i) amplitude and (ii) sensitivity to passive flexion and (iii) flexion test. Since the improvement of these parameters can be correlated with a lower perception of the pain, the present data suggest that the CSE treatment can have an analgesic effect in horses affected by chronic osteoarthritic diseases. The extract of the seeds from Indian celery, Apium greaveolens (CSE), tested in experimental animals (rodents), and in humans affected by chronic osteoarthritic diseases, exhibits anti-inflammatory effects that can be compared, to some degree, to those of non-steroid anti-inflammatory drugs (NSAID). In view of a potential use of CSE in the equine species, it was tested on horses affected by chronic articular pathologies. The trial was performed on 20 horses divided into three different groups, orally treated with 0 (controls), 7.0 or 30 g of CSE BID. Basic orthopedic examinations were conducted, vital signs were observed, and blood samples collected. Improvement was observed at the highest dosage tested (30 g of CSE BID), as reflected in the score values of three clinical parameters, (i) amplitude and (ii) sensitivity to passive flexion and (iii) flexion test. Since the improvement of these parameters can be correlated with a lower perception of the pain, the present data suggest that the CSE treatment can have an analgesic effect in horses affected by chronic osteoarthritic diseases.The extract of the seeds from Indian celery, Apium greaveolens (CSE), tested in experimental animals (rodents), and in humans affected by chronic osteoarthritic diseases, exhibits anti-inflammatory effects that can be compared, to some degree, to those of non-steroid anti-inflammatory drugs (NSAID). In view of a potential use of CSE in the equine species, it was tested on horses affected by chronic articular pathologies. The trial was performed on 20 horses divided into three different groups, orally treated with 0 (controls), 7.0 or 30 g of CSE BID. Basic orthopedic examinations were conducted, vital signs were observed, and blood samples collected. Improvement was observed at the highest dosage tested (30 g of CSE BID), as reflected in the score values of three clinical parameters, (i) amplitude and (ii) sensitivity to passive flexion and (iii) flexion test. Since the improvement of these parameters can be correlated with a lower perception of the pain, the present data suggest that the CSE treatment can have an analgesic effect in horses affected by chronic osteoarthritic diseases.
Author	Paci, Massimiliano Aldigeri, Raffaella Angelone, Mario Ramoni, Roberto Del Bue, Maurizio Quintavalla, Fausto Bussolati, Simona Vera, Elena Battaglia, Beatrice Basini, Giuseppina Grolli, Stefano
AuthorAffiliation	2 Dipartimento di Medicina e Chirurgia, Università di Parma, Via Gramsci 14, 43126 Parma, Italy 1 Dipartimento Scienze Medico Veterinarie, Università di Parma, Via del Taglio 10, 43126 Parma, Italy
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Cites_doi	10.1111/j.1939-1676.2012.00976.x 10.1007/s10787-010-0049-1 10.1080/10408398.2011.586740 10.1016/j.tvjl.2004.07.008 10.1016/j.cveq.2005.08.004 10.2460/javma.1993.202.01.71 10.1053/rvsc.2001.0513 10.1097/00003086-197310000-00018 10.1080/10286020.2017.1381687 10.1163/156856001300248470 10.2460/ajvr.2001.62.1916 10.1007/BF02918382 10.1078/0944-7113-00131 10.1016/j.mcna.2008.08.009 10.1111/j.1939-1676.2007.tb02995.x 10.1294/jes.27.125 10.1016/j.cveq.2008.03.004 10.1006/abio.1996.0292 10.1211/jpp.59.6.0016 10.1302/2046-3758.111.2000132
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SubjectTerms	analgesic effect anti-inflammatory activity anti-inflammatory agents Apium graveolens Arthritis blood sampling celery chronic orthopedic disorders dosage Drug dosages exhibitions Horses humans laboratory animals natural extract NSAID orthopedics osteoarthritis Pain phytotherapy rodents seeds
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Title	Clinical Effects of the Extract of the Seeds of the Indian Celery—Apium graveolens—In Horses Affected by Chronic Osteoarthritis
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