Clinical Effects of the Extract of the Seeds of the Indian Celery—Apium graveolens—In Horses Affected by Chronic Osteoarthritis

The extract of the seeds from Indian celery, Apium greaveolens (CSE), tested in experimental animals (rodents), and in humans affected by chronic osteoarthritic diseases, exhibits anti-inflammatory effects that can be compared, to some degree, to those of non-steroid anti-inflammatory drugs (NSAID)....

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Published inAnimals (Basel) Vol. 9; no. 8; p. 585
Main Authors Battaglia, Beatrice, Angelone, Mario, Vera, Elena, Basini, Giuseppina, Bussolati, Simona, Paci, Massimiliano, Del Bue, Maurizio, Aldigeri, Raffaella, Grolli, Stefano, Quintavalla, Fausto, Ramoni, Roberto
Format Journal Article
LanguageEnglish
Published Switzerland MDPI AG 20.08.2019
MDPI
Subjects
analgesic effect
anti-inflammatory activity
anti-inflammatory agents
Apium graveolens
Arthritis
blood sampling
celery
chronic orthopedic disorders
dosage
Drug dosages
exhibitions
Horses
humans
laboratory animals
natural extract
NSAID
orthopedics
osteoarthritis
Pain
phytotherapy
rodents
seeds
apium graveolens
natural extract
NSAID
osteoarthritis
phytotherapy
chronic orthopedic disorders
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Summary:The extract of the seeds from Indian celery, Apium greaveolens (CSE), tested in experimental animals (rodents), and in humans affected by chronic osteoarthritic diseases, exhibits anti-inflammatory effects that can be compared, to some degree, to those of non-steroid anti-inflammatory drugs (NSAID). In view of a potential use of CSE in the equine species, it was tested on horses affected by chronic articular pathologies. The trial was performed on 20 horses divided into three different groups, orally treated with 0 (controls), 7.0 or 30 g of CSE BID. Basic orthopedic examinations were conducted, vital signs were observed, and blood samples collected. Improvement was observed at the highest dosage tested (30 g of CSE BID), as reflected in the score values of three clinical parameters, (i) amplitude and (ii) sensitivity to passive flexion and (iii) flexion test. Since the improvement of these parameters can be correlated with a lower perception of the pain, the present data suggest that the CSE treatment can have an analgesic effect in horses affected by chronic osteoarthritic diseases.
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ISSN:2076-2615
2076-2615
DOI:10.3390/ani9080585