The Influence of Equipment Design and Process Parameters on Granule Breakage in a Semi-Continuous Fluid Bed Dryer after Continuous Twin-Screw Wet Granulation

• Published in: Pharmaceutics Vol. 13; no. 2; p. 293
• Main Authors: Ryckaert, Alexander, Ghijs, Michael, Portier, Christoph, Djuric, Dejan, Funke, Adrian, Vervaet, Chris, De Beer, Thomas
• Format: Journal Article
• Language: English
• Published: Switzerland MDPI AG 23.02.2021; MDPI
• Subjects: continuous manufacturing; Design; fluid bed drying; Investigations; Manufacturing; Moisture content; particle size distribution; Pharmaceutical industry; process understanding; twin-screw granulation; Belgium; United States > US; Switzerland; Germany; twin-screw granulation; granules; process understanding; continuous manufacturing; particle size distribution; fluid bed drying; moisture content

The drying unit of a continuous from-powder-to-tablet manufacturing line based on twin-screw granulation (TSG) is a crucial intermediate process step to achieve the desired tablet quality. Understanding the size reduction of pharmaceutical granules before, during, and after the fluid bed drying proc...