Some neuropharmacological effects of an ethanolic extract of Maprounea africana in rodents

• Published in: Journal of ethnopharmacology Vol. 43; no. 3; pp. 161 - 166
• Main Authors: N'gouemo, P., Nguemby-Bina, C., Baldy-Moulinier, M.
• Format: Journal Article
• Language: English
• Published: Shannon Elsevier Ireland Ltd 22.07.1994; Elsevier
• Subjects: Animals; Anticonvulsants - pharmacology; Biological and medical sciences; Body Temperature - drug effects; Congo; Convulsions; drugs; Ethanolic extract; Euphorbiaceae; General pharmacology; Hypnosis; Hypnotics and Sedatives - pharmacology; Hypothermia; Leaves; Male; Maprounea africana; Medical sciences; medicinal plants; medicinal properties; Medicine, African Traditional; Mice; Pharmacognosy. Homeopathy. Health food; pharmacology; Pharmacology. Drug treatments; plant extracts; Plant Extracts - pharmacology; Plants, Medicinal; Rats; Rats, Wistar; Rodents; traditional medicine; Tropical medicine; Republic of the Congo; Congo; Africa; Maprounea africana; Leaves; Ethanolic extract; Rodents; Hypnosis; Convulsions; Hypothermia; Pharmacognosy; Toxicity; Acute; Rodentia; Hypnotic; Anticonvulsant; Extract; Plant leaf; Biological activity; Medicinal plant; Vertebrata; Mammalia; Folk medicine; Mouse; Dicotyledones; Animal; Angiospermae; Plant origin; Euphorbiaceae; Spermatophyta
• ISSN: 0378-8741; 1872-7573
• DOI: 10.1016/0378-8741(94)90037-X

The ethanolic extract of the leaves of Maprounea africana (Euphorbiaceae), a medicinal plant in the Congolese traditional medicine, induced hypothermia and reduced the latency to the loss of the righting reflex and prolonged the sleeping time induced by pentobarbital in mice. It also significantly delayed the onset of clonic convulsions induced by pentylenetetrazole in mice. However, the extract did not affect either generalized convulsions induced by maximal electroshock and picrotoxin or limbic status epilepticus produced by pilocarpine and kainic acid.