Altered Composition of Gut Microbiota in Depression: A Systematic Review
Cumulative evidence shows a linkage between gut microbiota pattern and depression through the brain-gut microbiome axis. The aim of this systematic review was to identify the alterations of the gut microbiota patterns in people with depression compared to healthy controls. A comprehensive literature...
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Published in | Frontiers in psychiatry Vol. 11; p. 541 |
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Main Authors | , , , , |
Format | Journal Article |
Language | English |
Published |
Frontiers Media S.A
10.06.2020
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Subjects | |
Online Access | Get full text |
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Summary: | Cumulative evidence shows a linkage between gut microbiota pattern and depression through the brain-gut microbiome axis. The aim of this systematic review was to identify the alterations of the gut microbiota patterns in people with depression compared to healthy controls. A comprehensive literature search of human studies, published between January 2000 and June 2019, was reviewed. The key words included gastrointestinal microbiome, gut microbiome, microbiota, depression, depressive symptoms, and depressive disorder. The systematic review adhered to the Preferred Reporting Items for Systematic Reviews and Meta-Analysis (PRISMA) guidelines. Nine articles met the eligibility criteria. Disparities in α-diversity and β-diversity of the microbiota existed in people with depression compared to healthy controls. At the phylum level, there were inconsistencies in the abundance of
Firmicutes
,
Bacteroidetes
,
and Proteobacteria
. However, high abundance in
Actinobacteria
and
Fusobacteria
phyla were observed in people with depression. On the family level, high abundance of
Actinomycineae
,
Coriobacterineae
,
Bifidobacteriaceae
,
Clostridiales incertae sedis XI
,
Porphyromonadaceae
,
Clostridiaceae
,
Lactobacillaceae
,
Streptococcaceae
,
Eubacteriaceae
,
Thermoanaerobacteriaceae
,
Fusobacteriaceae
,
Nocardiaceae
,
Streptomycetaceae
,
and
low abundance of
Veillonellaceae
,
Prevotellaceae
,
Bacteroidaceae
,
Sutterellaceae
,
Oscillospiraceae
,
Marniabilaceae
, and
Chitinophagaceae
were observed in people with depression. On the genus level, high abundance of
Oscillibacter
,
Blautia
,
Holdemania
,
Clostridium XIX
,
Anaerostipes
,
Anaerofilum
,
Streptococcus
,
Gelria
,
Turicibacter
,
Parabacteroides
,
Eggerthella
,
Klebsiella
,
Paraprevotella
,
Veillonella
,
Clostridium IV
,
Erysipelotrichaceae incertae sedis
,
Eubacterium
,
Parvimonas
,
Desulfovibrio
,
Parasutterella
,
Actinomyces
,
Asaccharobacter
,
Atopobium
,
Olsenella
and low abundance of
Coprococcus
,
Lactobacillus
,
Escherichia/Shigella
,
Clostridium XlVa
,
Dialister
,
Howardella
,
Pyramidobacter
, and
Sutterella
were found in people with depression. Alteration of gut microbiome patterns was evident in people with depression. Further evidence is warranted to allow for the translation of microbiome findings toward innovative clinical strategies that may improve treatment outcomes in people with depression. |
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Bibliography: | content type line 23 SourceType-Scholarly Journals-1 Reviewed by: James Chong, University of York, United Kingdom; Kelly Robert Redeker, University of York, United Kingdom This article was submitted to Psychosomatic Medicine, a section of the journal Frontiers in Psychiatry Edited by: Christina Maria Van Der Feltz-Cornelis, University of York, United Kingdom |
ISSN: | 1664-0640 1664-0640 |
DOI: | 10.3389/fpsyt.2020.00541 |