Wnt/Fz signaling and the cytoskeleton: potential roles in tumorigenesis

Wnt/β-catenin regulates cellular functions related to tumor initiation and progression, cell proliferation, differentiation, survival, and adhesion. β-Catenin-independent Wnt pathways have been proposed to regulate cell polarity and migration, including metastasis. In this review, we discuss the pos...

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Bibliographic Details
Published inCell research Vol. 19; no. 5; pp. 532 - 545
Main Authors Lai, Shih-Lei, Chien, Andy J, Moon, Randall T
Format Journal Article
LanguageEnglish
Published London Nature Publishing Group UK 01.05.2009
Nature Publishing Group
Subjects
Adhesion
beta Catenin - metabolism
Biomedical and Life Sciences
Cell Adhesion
Cell Biology
Cilia - metabolism
Cytoskeleton - metabolism
Frizzled Receptors - metabolism
Humans
Life Sciences
Neoplasms - etiology
Neoplasms - metabolism
review
rho GTP-Binding Proteins - metabolism
Signal Transduction
Tumors
Wnt Proteins - metabolism
Rho
cilia
Wnt
cytoskeleton
cell adhesion
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Summary:Wnt/β-catenin regulates cellular functions related to tumor initiation and progression, cell proliferation, differentiation, survival, and adhesion. β-Catenin-independent Wnt pathways have been proposed to regulate cell polarity and migration, including metastasis. In this review, we discuss the possible roles of both β-catenin-dependent and -independent signaling pathways in tumor progression, with an emphasis on their regulation of Rho-family GTPases, cytoskeletal remodeling, and relationships with cell-cell adhesion and cilia/ciliogenesis.
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ISSN:1001-0602
1748-7838
DOI:10.1038/cr.2009.41