Coley's toxins, tumor necrosis factor and cancer research: A historical perspective

As far back of the 1700s, it was recorded that certain infectious disease processes could be exert beneficial therapeutic effect upon malignancy. Most prominent among the numerous deliberate efforts made to take advantage of these observations was that of a pioneering New York surgeon, William B. Co...

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Bibliographic Details
Published inPharmacology & therapeutics (Oxford) Vol. 64; no. 3; pp. 529 - 564
Main Authors Wiemann, Bernadette, Starnes, Charlie O.
Format Journal Article
LanguageEnglish
Published England Elsevier Inc 1994
Subjects
Bacterial Toxins - therapeutic use
Bacterial Vaccines - history
Bacterial Vaccines - therapeutic use
Coley
erysipelas
Erysipelas - complications
Erysipelas - immunology
History of medicine
History, 19th Century
History, 20th Century
Humans
Immunotherapy - history
mesodermal
Neoplasms - history
Neoplasms - immunology
Neoplasms - therapy
sarcoma
Sarcoma - history
Sarcoma - immunology
Sarcoma - therapy
TNF
Tumor Necrosis Factor-alpha - therapeutic use
United States
United States
Coley
mesodermal
erysipelas
sarcoma
IL
BCG
LIF
Spe
TNF
LPS
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Summary:As far back of the 1700s, it was recorded that certain infectious disease processes could be exert beneficial therapeutic effect upon malignancy. Most prominent among the numerous deliberate efforts made to take advantage of these observations was that of a pioneering New York surgeon, William B. Coley, active career 1891–1936. Using a bacterial vaccine to treat primarily inoperable sarcoma, Coley accomplished a cure rate of better than 10%. This review examines the history of these efforts and presents a discussion of their corresponding relevance to present day immunotherapy.
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ISSN:0163-7258
1879-016X
DOI:10.1016/0163-7258(94)90023-X