Biosynthetic studies on water-soluble derivative 5c (DTX5c)

The dinoflagellate Prorocentrum belizeanum is responsible for the production of several toxins involved in the red tide phenomenon known as Diarrhetic Shellfish Poisoning (DSP). In this paper we report on the biosynthetic origin of an okadaic acid water-soluble ester derivative, DTX5c, on the basis...

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Published inMarine drugs Vol. 10; no. 10; pp. 2234 - 2245
Main Authors Vilches, Tamara S, Norte, Manuel, Daranas, Antonio Hernández, Fernández, José J
Format Journal Article
LanguageEnglish
Published Switzerland MDPI AG 01.10.2012
MDPI
Subjects
biosynthesis
Dinoflagellida - metabolism
DSP
Marine
marine polyether
marine toxin
Molecular Structure
Okadaic Acid - analogs & derivatives
Okadaic Acid - chemistry
Okadaic Acid - metabolism
polyketide
Prorocentrum belizeanum
DSP
marine polyether
marine toxin
polyketide
biosynthesis
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Summary:The dinoflagellate Prorocentrum belizeanum is responsible for the production of several toxins involved in the red tide phenomenon known as Diarrhetic Shellfish Poisoning (DSP). In this paper we report on the biosynthetic origin of an okadaic acid water-soluble ester derivative, DTX5c, on the basis of the spectroscopical analysis of ¹³C enriched samples obtained by addition of labelled sodium [l-¹³C], [2-¹³C] acetate to artificial cultures of this dinoflagellate.
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ISSN:1660-3397
1660-3397
DOI:10.3390/md10102234