TERATOGENESIS OF THE HORSESHOE CRAB BY α-LIPOIC AMIDE (6, 8-THIOCTIC AMIDE) IN MARKETED VITAMIN TABLETS

Some marketed vitamin tablets induce defects and fusion of body segments and appendages in the developing horseshoe crab. α-Lipoic amide may be responsible for the induction, and the other vitamins are probably not directly responsible. α-Lipoic acid also induces the same malformations. It is presum...

Full description

Saved in:
Bibliographic Details
Published inJournal of Nutritional Science and Vitaminology Vol. 26; no. 3; pp. 237 - 245
Main Author ITOW, Tomio
Format Journal Article
LanguageEnglish
Published Japan Center for Academic Publications Japan 1980
Subjects
Abnormalities, Drug-Induced
animalization
Animals
defects of appendages
Female
Horseshoe Crabs - drug effects
Limb Deformities, Congenital
Male
teratogenesis by vitamin tablets
the horseshoe crab
Thioctic Acid - analogs & derivatives
Thioctic Acid - toxicity
Vitamins - pharmacology
α-lipoic acid
α-lipoic amide
Online AccessGet full text

Cover

More Information
Summary:Some marketed vitamin tablets induce defects and fusion of body segments and appendages in the developing horseshoe crab. α-Lipoic amide may be responsible for the induction, and the other vitamins are probably not directly responsible. α-Lipoic acid also induces the same malformations. It is presumed that α-Lipoic amide and α-lipoic acid inhibit thioldisulphide exchange and this inhibition disturbs the morphogenetic movement. As a result, the monsters may be induced by treatment with vitamin tablets.
ISSN:0301-4800
1881-7742
DOI:10.3177/jnsv.26.237