Incidence of Histoplasmosis in a Cohort of People with HIV: From Estimations to Reality

Among people with HIV, histoplasmosis represents an important cause of mortality. Previous studies provided estimates of the disease incidence. Here, we compared those estimates with the results obtained from a screening program implemented in Guatemala, which included histoplasmosis detection for p...

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Published inMicroorganisms (Basel) Vol. 9; no. 12; p. 2596
Main Authors Medina, Narda, Rodriguez-Tudela, Juan Luis, Aguirre, Luis, Salazar, Luis R, Gamboa, Osmar, Bonilla, Oscar, Pérez, Juan C, Arathoon, Eduardo, Denning, David W, Alastruey-Izquierdo, Ana
Format Journal Article
LanguageEnglish
Published Switzerland MDPI AG 16.12.2021
MDPI
Subjects
antigen
Antigens
Disease
Estimates
Health facilities
Histoplasmosis
HIV
Human immunodeficiency virus
Infections
Laboratories
Mortality
opportunistic infections
Quality control
Statistical analysis
Trends
Tuberculosis
Guatemala
opportunistic infections
antigen
histoplasmosis
HIV
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Summary:Among people with HIV, histoplasmosis represents an important cause of mortality. Previous studies provided estimates of the disease incidence. Here, we compared those estimates with the results obtained from a screening program implemented in Guatemala, which included histoplasmosis detection for people with HIV. To compare the results of this program with previous estimations, a literature search was performed and reports concerning histoplasmosis incidence were analyzed. The screening program enrolled 6366 patients. The overall histoplasmosis incidence in the screening program was 7.4%, which was almost double that estimated in previous studies. From 2017 to 2019, the screening program showed an upward trend in histoplasmosis cases from 6.5% to 8.8%. Histoplasmosis overall mortality among those who were newly HIV diagnosed showed a decrease at 180 days from 32.8% in 2017 to 21.2% in 2019. The screening approach using rapid diagnostic assays detects histoplasmosis cases more quickly, allowing a specific treatment to be administered, which decreases the mortality of the disease. Therefore, the use of these new techniques, especially in endemic areas of histoplasmosis, must be implemented.
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This work was stated by the authors on behalf of Fungired.
ISSN:2076-2607
2076-2607
DOI:10.3390/microorganisms9122596