Development of Direct Aromatic Coupling Reactions by Transition-Metal Catalysis

Transition-metal-catalyzed aromatic cross-coupling reactions are highly useful for constructing various organic fine chemicals. The conventional methods, however, usually require the preactivation of aromatic substrates such as stoichiometric halogenation and metalation before the coupling event, wh...

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Bibliographic Details
Published inBulletin of the Chemical Society of Japan Vol. 87; no. 7; pp. 751 - 764
Main Authors Miura, Masahiro, Satoh, Tetsuya, Hirano, Koji
Format Journal Article
LanguageEnglish
Published Tokyo The Chemical Society of Japan 2014
Chemical Society of Japan
SeriesThe Chemical Society of Japan Award for Creative Work for 2012
Subjects
Byproducts
Catalysis
Catalysts
Coupling (molecular)
Halogenation
Synthesis
Transformations
Transition metals
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Summary:Transition-metal-catalyzed aromatic cross-coupling reactions are highly useful for constructing various organic fine chemicals. The conventional methods, however, usually require the preactivation of aromatic substrates such as stoichiometric halogenation and metalation before the coupling event, which increases the steps leading to target molecules and yields inevitable salts as by-products. In order to cope with these problems, catalytic C–H transformation reactions on aromatic substrates have been one of the most intensive subjects in the area of catalytic organic synthesis. Summarized herein are our efforts for developing direct aromatic and heteroaromatic coupling reactions by using a number of transition metals as catalysts.
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ISSN:0009-2673
1348-0634
DOI:10.1246/bcsj.20140099