Systematic management of osteoradionecrosis in the head and neck

• Published in: The Laryngoscope Vol. 109; no. 8; p. 1324
• Main Authors: Hao, S P, Chen, H C, Wei, F C, Chen, C Y, Yeh, A R, Su, J L
• Format: Journal Article
• Language: English
• Published: United States 01.08.1999
• Subjects: Bone Diseases - etiology; Bone Diseases - therapy; Carcinoma - radiotherapy; Combined Modality Therapy; Female; Humans; Hyperbaric Oxygenation - methods; Male; Mandible - surgery; Maxilla - surgery; Nasopharyngeal Neoplasms - radiotherapy; Neoplasm Recurrence, Local; Osteoradionecrosis - etiology; Osteoradionecrosis - therapy; Prospective Studies; Radiotherapy Dosage; Temporal Bone - surgery
• ISSN: 0023-852X
• DOI: 10.1097/00005537-199908000-00027

Osteoradionecrosis is one of the most serious and devastating complications of radiotherapy. The proper management of osteoradionecrosis is currently undetermined. The objective of this study is to evaluate the treatment results of a systematic approach to osteoradionecrosis. A prospective study of a systematic approach to osteoradionecrosis in the head and neck area was undertaken. From July 1993 to June 1998, 33 cases of osteoradionecrosis in the head and neck area were treated using a systematic approach that combined sequestrectomy and hyperbaric oxygen therapy. Seven (21%) had recurrent cancer. The control rate of the other 26 osteoradionecrosis cases was 77% (20/26). Persistent osteoradionecrosis, despite diligent radical treatment, raises the suspicion of recurrent cancer. Extensive osteoradionecrosis with a multiple discharging fistula, a large area of exposed necrotic bone, or a coexistent fracture should be treated primarily with radical sequestrectomy and microvascular free flap reconstruction. Surgery still plays a major role in controlling osteoradionecrosis, and hyperbaric oxygen therapy is adjuvant.