Anti-asialo-GM1 and GD1a Variant of Miller Fisher Variant of Guillain–Barré Syndrome

We present a woman with acute onset of bilateral ophthalmoparesis and ataxia occurring 4 weeks after gastroenteritis. Serum antibody titers against asialo-GM1 and GD1a, typically associated with inflammatory axonal neuropathies, were elevated but titers against anti-GQ1b, the most commonly found ant...

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Bibliographic Details
Published inJournal of neuro-ophthalmology Vol. 34; no. 4; pp. 377 - 379
Main Authors Morgan, Michael L, Law, Nathan, Espino Barros Palau, Angelina, Saeed, Umair, Yalmanchili, Sushma, Lee, Andrew G
Format Journal Article
LanguageEnglish
Published United States by North American Neuro-Ophthalmology Society 01.12.2014
Subjects
Adult
Autoantibodies - blood
Female
G(M1) Ganglioside - immunology
Gangliosides - immunology
Humans
Miller Fisher Syndrome - blood
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Summary:We present a woman with acute onset of bilateral ophthalmoparesis and ataxia occurring 4 weeks after gastroenteritis. Serum antibody titers against asialo-GM1 and GD1a, typically associated with inflammatory axonal neuropathies, were elevated but titers against anti-GQ1b, the most commonly found antibody found in the Miller Fisher variant of Guillain–Barre syndrome were not. No other etiology for ophthalmoparesis was found despite extensive patient evaluation. Intravenous immunoglobulin was administered, and the patient gradually improved over subsequent months. This case is unique for its antiganglioside antibody profile associated with Miller Fisher syndrome.
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ISSN:1070-8022
1536-5166
DOI:10.1097/WNO.0000000000000156