Imbalance of CD4 + CD45R+ and CD4+ CD29+ T helper cell subsets in patients with atopic diseases
SUMMARY To evaluate the proportion of helper cell subsets we studied 18 children with atopic dermatitis, 30 patients with asthma. 27 healthy age‐matched controls aged 1 to 17 years and 11 atopic controls without symptoms related to atopy, aged 9–22 years. Lymphocytes were isolated from heparinized p...
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Published in | Clinical and experimental immunology Vol. 83; no. 1; pp. 25 - 29 |
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Main Authors | , , , |
Format | Journal Article |
Language | English |
Published |
Oxford, UK
Blackwell Publishing Ltd
01.01.1991
Blackwell |
Subjects | |
Online Access | Get full text |
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Summary: | SUMMARY
To evaluate the proportion of helper cell subsets we studied 18 children with atopic dermatitis, 30 patients with asthma. 27 healthy age‐matched controls aged 1 to 17 years and 11 atopic controls without symptoms related to atopy, aged 9–22 years. Lymphocytes were isolated from heparinized peripheral blood and the proportion of CD4+CD29+ and CD4+CD45R+ cells was determined by double‐labelling immunofluorescence. Children with atopic dermatitis yielded a significantly (P<0.0l) higher proportion of CD4+CD45R+ (median 75%) cells compared with normal controls (median 66.6%). whereas the proportion of CD4+CD29+ cells was significantly (P<0.0l) lower in patients with atopic dermatitis (median 204 versus 29.6%). Interestingly, the percentage of CD4+CD45R+ cells shows an age‐dependent decline (r= ‐0.67, P<0.0l) in the control group, which is not found in the patient group. |
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Bibliography: | ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 content type line 23 |
ISSN: | 0009-9104 1365-2249 |
DOI: | 10.1111/j.1365-2249.1991.tb05582.x |