Electrooxidative Rhodium‐Catalyzed [5+2] Annulations via C−H/O−H Activations
Electrooxidative annulations involving mild transition metal‐catalyzed C−H activation have emerged as a transformative strategy for the rapid construction of five‐ and six‐membered heterocycles. In contrast, we herein describe the first electrochemical metal‐catalyzed [5+2] cycloadditions to assembl...
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Published in | Angewandte Chemie International Edition Vol. 60; no. 12; pp. 6419 - 6424 |
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Main Authors | , , , |
Format | Journal Article |
Language | English |
Published |
WEINHEIM
Wiley
15.03.2021
Wiley Subscription Services, Inc John Wiley and Sons Inc |
Edition | International ed. in English |
Subjects | |
Online Access | Get full text |
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Summary: | Electrooxidative annulations involving mild transition metal‐catalyzed C−H activation have emerged as a transformative strategy for the rapid construction of five‐ and six‐membered heterocycles. In contrast, we herein describe the first electrochemical metal‐catalyzed [5+2] cycloadditions to assemble valuable seven‐membered benzoxepine skeletons by C−H/O−H activation. The efficient alkyne annulation featured ample substrate scope, using electricity as the only oxidant. Mechanistic studies provided strong support for a rhodium(III/I) regime, involving a benzoxepine‐coordinated rhodium(I) sandwich complex as the catalyst resting state, which was re‐oxidized to rhodium(III) by anodic oxidation.
Electrochemical rhodium‐catalyzed [5+2] cycloadditions to assemble seven‐membered benzoxepines have been accomplished guided by detailed mechanistic insights. |
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Bibliography: | ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 content type line 23 |
ISSN: | 1433-7851 1521-3773 |
DOI: | 10.1002/anie.202016895 |