pH responsive polymers with amino acids in the side chains and their potential applications

• Published in: Journal of applied polymer science Vol. 131; no. 20; pp. np - n/a
• Main Authors: Roy, Saswati Ghosh, De, Priyadarsi
• Format: Journal Article
• Language: English
• Published: Hoboken, NJ Blackwell Publishing Ltd 15.10.2014; Wiley; Wiley Subscription Services, Inc
• Subjects: Amino acids; Applied sciences; biocompatibility; Biological and medical sciences; Biomolecules; Drug delivery systems; Exact sciences and technology; General pharmacology; Macromolecules; Materials science; Medical sciences; Oil recovery; Organic polymers; Pharmaceutical technology. Pharmaceutical industry; Pharmacology. Drug treatments; Physicochemistry of polymers; Polymers; Polymers with particular properties; Preparation, kinetics, thermodynamics, mechanism and catalysts; stimuli-sensitive polymers; Synthesis; Biological properties; Methacrylate polymer; drug delivery systems; stimuli-sensitive polymers; State of the art; Control release polymer; Drug carrier; Acrylamide derivative copolymer; pH effect; Side chain; Aminoacid; Preparation; Dipeptides; Biocompatibility; Gene therapy; Block copolymer; Amphiphilic polymer
• ISSN: 0021-8995; 1097-4628
• DOI: 10.1002/app.41084

ABSTRACT Design and synthesis of pH responsive polymeric materials has become an important subject in academia as well as in industrial field in recent years due to their applications in diverse field including controlled drug delivery, biomedical applications, membrane science, sensors and actuators, oil recovery, colloid stabilization, etc. Efforts have been made to incorporate stimuli‐responsive biomolecules in synthetic polymers to develop pH responsive “smart” non‐biological hybrid macromolecules with high water solubility, enhanced biocompatibility, bio‐mimetic structure and properties. This review is focused on the recent advances in side‐chain amino acid‐based pH responsive polymers synthesis and potential application aspects of these macromolecular architectures in drug and gene delivery, and other fields. © 2014 Wiley Periodicals, Inc. J. Appl. Polym. Sci. 2014, 131, 41084.