Synthetic Ellagic Acid Glycosides Inhibit Early Stage Adhesion of Streptococcus agalactiae Biofilms as Observed by Scanning Electron Microscopy
Ellagic acid derivatives possess antimicrobial and antibiofilm properties across a wide‐range of microbial pathogens. Due to their poor solubility and ambident reactivity it is challenging to synthesize, purify, and characterize the activity of ellagic acid glycosides. In this study, we have synthes...
Saved in:
Published in | Chemistry : a European journal Vol. 26; no. 44; pp. 9923 - 9928 |
---|---|
Main Authors | , , |
Format | Journal Article |
Language | English |
Published |
WEINHEIM
Wiley
06.08.2020
Wiley Subscription Services, Inc |
Subjects | |
Online Access | Get full text |
Cover
Loading…
Summary: | Ellagic acid derivatives possess antimicrobial and antibiofilm properties across a wide‐range of microbial pathogens. Due to their poor solubility and ambident reactivity it is challenging to synthesize, purify, and characterize the activity of ellagic acid glycosides. In this study, we have synthesized three ellagic acid glycoconjugates and evaluated their antimicrobial and antibiofilm activity in Streptococcus agalactiae (Group B Streptococcus, GBS). Their significant impacts on biofilm formation were examined via SEM to reveal early‐stage inhibition of cellular adhesion. Additionally, the synthetic glycosides were evaluated against five of the six ESKAPE pathogens and two fungal pathogens. These studies reveal that the ellagic acid glycosides possess inhibitory effects on the growth of gram‐negative pathogens.
Synthetic ellagic acid glycosides possess carbohydrate‐specific antibiofilm activity against Streptococcus agalactiae. SEM has revealed that these compounds likely inhibit early stage bacterial adhesion mechanisms. Additionally, these compounds possess antimicrobial activity against gram‐negative ESKAPE pathogens, further broadening the antibiotic profile of synthetic ellagic acid glycosides (see figure). |
---|---|
Bibliography: | ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 content type line 23 Institute and/or researcher Twitter usernames: @Townsend_Lab @VanderbiltChem |
ISSN: | 0947-6539 1521-3765 |
DOI: | 10.1002/chem.202000354 |