Influence of chronic lead exposure on hormone levels in developing rats

The effect of five months' exposure to 0.5% lead acetate in drinking water on hormone levels of developing rats was studied. The hypothalamic and striatic concentrations of noradrenaline (NA) were decreased in both sexes. In female but not in male rats, blood and adrenal catecholamines and seru...

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Bibliographic Details
Published inJournal of applied toxicology Vol. 10; no. 4; p. 301
Main Authors Vyskocil, A, Fiala, Z, Ettlerová, E, Tenjnorová, I
Format Journal Article
LanguageEnglish
Published England 01.08.1990
Subjects
Animals
Catecholamines - blood
Corpus Striatum - drug effects
Corpus Striatum - metabolism
Corticosterone - blood
Drinking - drug effects
Female
Hormones - blood
Hypothalamus - drug effects
Hypothalamus - metabolism
Lead Poisoning - metabolism
Male
Norepinephrine - blood
Rats
Rats, Inbred Strains
Sex Factors
Thyroxine - blood
Triiodothyronine - blood
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Summary:The effect of five months' exposure to 0.5% lead acetate in drinking water on hormone levels of developing rats was studied. The hypothalamic and striatic concentrations of noradrenaline (NA) were decreased in both sexes. In female but not in male rats, blood and adrenal catecholamines and serum corticosterone concentrations were also increased. No changes were observed in serum thyroxine and 3,5,3'-triiodothyronine levels. Our results indicate that female developing rats are more susceptible to lead than male rats. In female rats, both the hypothalamo-pituitary-adrenal and sympatho-adrenal systems seem to be affected by this lead exposure; in male rats, only the latter system is affected.
ISSN:0260-437X
DOI:10.1002/jat.2550100412