A comparative genomic view of clostridial sporulation and physiology

Clostridia are anaerobic, endospore-forming prokaryotes that include strains of importance to human and animal health and physiology, cellulose degradation, solvent production and bioremediation. Their differentiation and related developmental programmes are not well understood at the molecular leve...

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Bibliographic Details
Published inNature reviews. Microbiology Vol. 3; no. 12; pp. 969 - 978
Main Authors Papoutsakis, Eleftherios T, Paredes, Carlos J, Alsaker, Keith V
Format Journal Article
LanguageEnglish
Published England Nature Publishing Group 01.12.2005
Subjects
Bacillus subtilis - genetics
Bacillus subtilis - physiology
Bacterial Proteins - metabolism
Bioremediation
Cellulose
Chemotaxis - genetics
Chemotaxis - physiology
Clostridium - genetics
Clostridium - physiology
Genomes
Genomics
Glycosylation
Kinases
Oxidation
Physiology
Protein Kinases - metabolism
Proteins
Solvents
Spores, Bacterial - physiology
Transcription Factors - metabolism
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Summary:Clostridia are anaerobic, endospore-forming prokaryotes that include strains of importance to human and animal health and physiology, cellulose degradation, solvent production and bioremediation. Their differentiation and related developmental programmes are not well understood at the molecular level. Recent genome sequencing and transcriptional-profiling studies have offered a glimpse of their inner workings and indicate that a better understanding of the orchestration of the molecular events that underlie their unique physiology, capabilities and diversity will pay major dividends.
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ISSN:1740-1526
1740-1534
DOI:10.1038/nrmicro1288