Removal of pinned scroll waves in cardiac tissues by electric fields in a generic model of three-dimensional excitable media

• Published in: Scientific reports Vol. 6; no. 1; p. 21876
• Main Authors: Pan, De-Bei, Gao, Xiang, Feng, Xia, Pan, Jun-Ting, Zhang, Hong
• Format: Journal Article
• Language: English
• Published: London Nature Publishing Group UK 24.02.2016; Nature Publishing Group
• Subjects: 631/443/592/75/29/1938; 639/766/530/2803; Arrhythmias, Cardiac - physiopathology; Cardiac arrhythmia; Electric fields; Electricity; Heart; Heart diseases; Humanities and Social Sciences; Humans; Media; Models, Biological; multidisciplinary; Plasma; Science
• ISSN: 2045-2322; 2045-2322
• DOI: 10.1038/srep21876

Spirals or scroll waves pinned to heterogeneities in cardiac tissues may cause lethal arrhythmias. To unpin these life-threatening spiral waves, methods of wave emission from heterogeneities (WEH) induced by low-voltage pulsed DC electric fields (PDCEFs) and circularly polarized electric fields (CPEFs) have been used in two-dimensional (2D) cardiac tissues. Nevertheless, the unpinning of scroll waves in three-dimensional (3D) cardiac systems is much more difficult than that of spiral waves in 2D cardiac systems, and there are few reports on the removal of pinned scroll waves in 3D cardiac tissues by electric fields. In this article, we investigate in detail the removal of pinned scroll waves in a generic model of 3D excitable media using PDCEF, AC electric field (ACEF) and CPEF, respectively. We find that spherical waves can be induced from the heterogeneities by these electric fields in initially quiescent excitable media. However, only CPEF can induce spherical waves with frequencies higher than that of the pinned scroll wave. Such higher-frequency spherical waves induced by CPEF can be used to drive the pinned scroll wave out of the cardiac systems. We hope this remarkable ability of CPEF can provide a better alternative to terminate arrhythmias caused by pinned scroll waves.