Genetic Variation in IL28B and Treatment-induced Clearance of Hepatitis C Virus in HIV-Positive Patients With Acute and Chronic Hepatitis C

• Published in: The Journal of infectious diseases Vol. 203; no. 5; pp. 595 - 601
• Main Authors: Nattermann, Jacob, Vogel, Martin, Nischalke, Hans Dieter, Danta, Mark, Mauss, Stefan, Stellbrink, Hans-Jörg, Baumgarten, Axel, Mayr, Christoph, Bruno, Raffaele, Tural, Cristina, Klausen, Gerd, Clotet, Bonaventura, Naumann, Uwe, Lutz, Thomas, Rausch, Michael, Schewe, Knud, Bienek, Bernhard, Haerter, Georg, Sauerbruch, Tilman, Rockstroh, Juergen K., Spengler, Ulrich
• Format: Journal Article
• Language: English
• Published: Oxford Oxford University Press 01.03.2011
• Subjects: Adult; Aged; Aged, 80 and over; Alleles; Biological and medical sciences; Case-Control Studies; CD4 Lymphocyte Count; Chronic hepatitis; Coinfection; Female; Fundamental and applied biological sciences. Psychology; Genotype; Genotypes; Hepacivirus; Hepacivirus - genetics; Hepatitis C; Hepatitis C - genetics; Hepatitis C - virology; Hepatitis C virus; HIV; HIV Infections - complications; HIV Infections - diagnosis; HIV Infections - genetics; HIV/AIDS; Human immunodeficiency virus; Human viral diseases; Humans; Infections; Infectious diseases; Interferons; Interleukins - genetics; Major and Brief Reports; Male; Medical sciences; Microbiology; Middle Aged; Miscellaneous; Polymorphism, Single Nucleotide; Regression Analysis; RNA; RNA, Viral - analysis; Treatment Outcome; Viral diseases; Viral diseases of the lymphoid tissue and the blood. Aids; Viral hepatitis; Virology; Immunopathology; Acute; Hepatic disease; AIDS; Immune deficiency; Virus; Infection; Treatment; Viral disease; Digestive diseases; Genetics; Flaviviridae; Hepatitis C virus; Hepacivirus; Viral hepatitis C
• ISSN: 0022-1899; 1537-6613; 1537-6613; 0022-1899
• DOI: 10.1093/infdis/jiq098

Recently, a IL28B (rs 12979860) gene polymorphism was identified as a predictor for response to hepatits C virus—specific treatment in human immunodeficiency virus (HIV)—uninfected and —infected patients with chronic hepatitis C. In an analysis of HIV-infected patients with acute hepatitis C, we found that the IL28B genotype was associated with serum levels of hepatitis C virus RNA, g-GT, and CD4 cell count. In contrast to HIV-infected patients with chronic hepatitis C, the IL28B genotype was not significantly associated with treatment response rates in patients with acute hepatitis C. Thus, effects of the IL28B single-nucleotide polymorphism may differ in HIV-infected patients with chronic and acute hepatitis C.