From Immunodeficiency to Humanization: The Contribution of Mouse Models to Explore HTLV-1 Leukemogenesis

The first discovered human retrovirus, Human T-Lymphotropic Virus type 1 (HTLV-1), is responsible for an aggressive form of T cell leukemia/lymphoma. Mouse models recapitulating the leukemogenesis process have been helpful for understanding the mechanisms underlying the pathogenesis of this retrovir...

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Published inViruses Vol. 7; no. 12; pp. 6371 - 6386
Main Authors Pérès, Eléonore, Bagdassarian, Eugénie, This, Sébastien, Villaudy, Julien, Rigal, Dominique, Gazzolo, Louis, Duc Dodon, Madeleine
Format Journal Article
LanguageEnglish
Published Switzerland MDPI 07.12.2015
MDPI AG
Subjects
adult T cell leukemia/lymphoma
Animals
Disease Models, Animal
Host-Pathogen Interactions
HTLV-1
Human T-lymphotropic virus 1 - growth & development
humanized mouse models
Humans
Leukemia-Lymphoma, Adult T-Cell - pathology
Leukemia-Lymphoma, Adult T-Cell - virology
Mice
Mice, SCID
oncogenesis
Review
adult T cell leukemia/lymphoma
HTLV-1
humanized mouse models
oncogenesis
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Summary:The first discovered human retrovirus, Human T-Lymphotropic Virus type 1 (HTLV-1), is responsible for an aggressive form of T cell leukemia/lymphoma. Mouse models recapitulating the leukemogenesis process have been helpful for understanding the mechanisms underlying the pathogenesis of this retroviral-induced disease. This review will focus on the recent advances in the generation of immunodeficient and human hemato-lymphoid system mice with a particular emphasis on the development of mouse models for HTLV-1-mediated pathogenesis, their present limitations and the challenges yet to be addressed.
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ObjectType-Review-1
ISSN:1999-4915
1999-4915
DOI:10.3390/v7122944