Investigation of the cellular reprogramming phenomenon referred to as stimulus-triggered acquisition of pluripotency (STAP)

In January 2014, it was reported that strong external stimuli, such as a transient low-pH stressor, was capable of inducing the reprogramming of mammalian somatic cells, resulting in the generation of pluripotent cells. This cellular reprograming event was designated ‘stimulus-triggered acquisition...

Full description

Saved in:
Bibliographic Details
Published inScientific reports Vol. 6; no. 1; p. 28003
Main Author Niwa, Hitoshi
Format Journal Article
LanguageEnglish
Published London Nature Publishing Group UK 13.06.2016
Nature Publishing Group
Subjects
13/100
631/532/2062
631/532/2435
Adenosine triphosphate
Aggregates
Cell death
Cell division
Embryos
Humanities and Social Sciences
Leukemia
Liver
multidisciplinary
Science
Science (multidisciplinary)
Spleen
Stem cells
Online AccessGet full text

Cover

More Information
Summary:In January 2014, it was reported that strong external stimuli, such as a transient low-pH stressor, was capable of inducing the reprogramming of mammalian somatic cells, resulting in the generation of pluripotent cells. This cellular reprograming event was designated ‘stimulus-triggered acquisition of pluripotency’ (STAP) by the authors of these reports. However, after multiple instances of scientific misconduct in the handling and presentation of the data were brought to light, both reports were retracted. To investigate the actual scientific significance of the purported STAP phenomenon, we sought to repeat the original experiments based on the methods presented in the retracted manuscripts and other relevant information. As a result, we have concluded that the STAP phenomenon as described in the original studies is not reproducible.
Bibliography:ObjectType-Article-1
SourceType-Scholarly Journals-1
ObjectType-Feature-2
content type line 23
ISSN:2045-2322
2045-2322
DOI:10.1038/srep28003