Questionnaire-based analysis of atovaquone–proguanil compared with mefloquine in the chemoprophylaxis of malaria in non-immune Japanese travelers
Abstract Malaria is one of the most common and serious infectious diseases in the tropics and subtropics. For high-risk travelers to endemic regions, malaria chemoprophylaxis is recommended. Internationally, atovaquone–proguanil (A/P), mefloquine (MEF), or doxycycline (DOX) are the prescribed malari...
Saved in:
Published in | Journal of infection and chemotherapy : official journal of the Japan Society of Chemotherapy Vol. 19; no. 1; pp. 20 - 23 |
---|---|
Main Authors | , , , , , |
Format | Journal Article |
Language | English |
Published |
Japan
Elsevier Ltd
01.02.2013
Springer Japan |
Subjects | |
Online Access | Get full text |
Cover
Loading…
Summary: | Abstract Malaria is one of the most common and serious infectious diseases in the tropics and subtropics. For high-risk travelers to endemic regions, malaria chemoprophylaxis is recommended. Internationally, atovaquone–proguanil (A/P), mefloquine (MEF), or doxycycline (DOX) are the prescribed malaria chemoprophylactic drugs. However, A/P and DOX are not approved in Japan. Therefore, the data on A/P for malaria chemoprophylaxis in Japanese travelers are not clear. We analyzed questionnaire survey data obtained in Hibiya Clinic to assess the safety and tolerability of A/P and compare them with those of MEF for non-immune Japanese travelers. A/P was given to 278 travelers and MEF to 38 travelers. The mean duration of each prophylaxis is for 20.0 ± 9.6 and 59.0 ± 15.9 days, respectively. Nine travelers discontinued prophylaxis: 5 in the A/P prescribed group (A/P group) and 4 in the MEF prescribed group (MEF group), and the rate of discontinuation was significantly less in the A/P group. The frequency of adverse events was significantly less in the A/P group than in the MEF group [52 cases (18.8 %) vs. 14 cases (36.8 %), respectively]. In particular, the frequency of psychoneurotic adverse events was significantly less in the A/P group. These results suggest that A/P is better tolerated and has fewer adverse events than MEF in non-immune Japanese travelers. |
---|---|
Bibliography: | ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 content type line 23 |
ISSN: | 1341-321X 1437-7780 |
DOI: | 10.1007/s10156-012-0446-z |