Adenylate Cyclase Toxin from Bordetella pertussis Synergizes with Lipopolysaccharide To Promote Innate Interleukin-10 Production and Enhances the Induction of Th2 and Regulatory T Cells

• Published in: Infection and Immunity Vol. 72; no. 3; pp. 1568 - 1579
• Main Authors: ROSS, Padraig J, LAVELLE, Ed C, MILLS, Kingston H. G, BOYD, Aoife P
• Format: Journal Article
• Language: English
• Published: Washington, DC American Society for Microbiology 01.03.2004
• Subjects: Adenylate Cyclase Toxin - administration & dosage; Adenylate Cyclase Toxin - genetics; Adenylate Cyclase Toxin - immunology; Adjuvants, Immunologic - administration & dosage; Animals; Bacteriology; Biological and medical sciences; Bordetella pertussis; Bordetella pertussis - genetics; Bordetella pertussis - immunology; Cell Differentiation - drug effects; Cloning, Molecular; Cytokines - biosynthesis; Dendritic Cells - cytology; Dendritic Cells - drug effects; Dendritic Cells - immunology; Drug Synergism; Female; Fundamental and applied biological sciences. Psychology; Host Response and Inflammation; Immunity, Innate; Immunoglobulin G - biosynthesis; immunoglobulin G1; In Vitro Techniques; Interleukin-10 - biosynthesis; lipopolysaccharides; Lipopolysaccharides - administration & dosage; Lipopolysaccharides - immunology; Membrane Glycoproteins - deficiency; Membrane Glycoproteins - genetics; Mice; Mice, Inbred BALB C; Mice, Inbred C3H; Microbiology; Miscellaneous; Receptors, Cell Surface - deficiency; Receptors, Cell Surface - genetics; Signal Transduction; T-Lymphocyte Subsets - drug effects; T-Lymphocyte Subsets - immunology; Th2 Cells - drug effects; Th2 Cells - immunology; Toll-Like Receptor 4; Toll-Like Receptors; Immune response; Enzyme; Rodentia; Phosphorus-oxygen lyases; Helper cell; Islet activating protein; Toll like receptor; Lyases; Bordetella pertussis; Polymyxin B; Infection; Adenylate cyclase; Vertebrata; Antibiotic; Mammalia; Mouse; Immunological adjuvant; Interleukin 10; T-Lymphocyte; Bacteriosis; Lipopolysaccharide; Bacteria; Th2 lymphocyte; Antibacterial agent
• ISSN: 0019-9567; 1098-5522
• DOI: 10.1128/IAI.72.3.1568-1579.2004

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