Toxicological Evaluation of Chicken-Breast Meat with High-Dose Irradiation

• Published in: Journal of Integrative Agriculture Vol. 11; no. 12; pp. 2088 - 2096
• Main Authors: ZHU, Jia-ting, FENG, Min, YAN, Jian-min, LIU, Chun-quan, HA, Yi-ming, GAO, Mei-xu, YANG, Ping, WANG, Zhi-dong, WANG, De-ning, LI, Shu-rong, GU, Gui-qiang
• Format: Journal Article
• Language: English
• Published: Elsevier B.V 01.12.2012; Science Press; Institute of Atomic Energy in Application for Agriculture,Jiangsu Academy of Agricultural Sciences, Nanjing 210014, P.R.China%Institute of Farm Product Processing, Jiangsu Academy of Agricultural Sciences, Nanjing 210014.P.R.China%Institute of Agro-Products Processing Science&Technology, Chinese Academy of Agricultural Sciences, Beijing 100193.P.R.China; KeAi Communications Co., Ltd
• Subjects: Ames试验; chicken-breast meat; irradiated, high dose; toxicological assessment; toxicological assessment chicken-breast meat irradiated high dose; 半数致死剂量; 急性毒性; 毒理学评价; 照射; 胸肌; 高剂量; 鸡胸脯肉; irradiated, high dose; chicken-breast meat; toxicological assessment; irradiated; high dose
• ISSN: 2095-3119; 2352-3425
• DOI: 10.1016/S2095-3119(12)60467-5

In this paper, toxicity and safety of high-dose irradiated chicken-breast meat were evaluated. For assays of acute toxicity, genetic toxicity, and sub-chronic toxicity, ames test, mice bone marrow erythrocyte micronucleus, and mice sperm abnormality were performed. The results showed that, in the acute oral toxicity tests, median lethal dose （more than 10 000 mg kg-~） in male and female ICR mice showed no toxicological signs. For subacute 30-d oral toxicology of irradiated chicken-breast meat with dose of 10, 15 and 25 kGy in both male and female SD rats, no noticeable toxicological effects were observed. It is concluded that chicken-breast meat with high-dose irradiation has no acute toxicity and no genotoxicity, nor harmful effects on the animal body at the tested dosage range. Therefore, high-dose irradiated chicken-breast meat is safe for pet consumption.