The anti-photoaging and moisturizing effects of Bouea macrophylla extract in UVB-irradiated hairless mice

• Published in: Food science and biotechnology Vol. 27; no. 1; pp. 147 - 157
• Main Authors: Cheong, Yongin, Kim, Changhee, Kim, Mi-Bo, Hwang, Jae-Kwan
• Format: Journal Article
• Language: English
• Published: Singapore Springer Singapore 01.02.2018; Springer Nature B.V; 한국식품과학회
• Subjects: Activator protein 1; Chemistry; Chemistry and Materials Science; Collagen; Collagen (type I); Collagenase 3; Dehydration; Elasticity; Filaggrin; Food Science; Gelatinase A; Gelatinase B; Hairless; Kinases; Matrix metalloproteinase; Metalloproteinase; Mice; Moisture content; mRNA; Nutrition; Oral administration; Proteins; Skin; Smad protein; Thickening; Transcription factors; Transforming growth factor; Ultraviolet radiation; Water content; 식품과학; Moisturizing effect; Anti-photoaging; Matrix metalloproteinase; Collagen; Bouea macrophylla
• ISSN: 1226-7708; 2092-6456; 2092-6456
• DOI: 10.1007/s10068-017-0276-y

Ultraviolet (UV) light, a main cause of photoaging, leads to collapse of skin structure, resulting in wrinkle formation and dehydration. The present study assessed the anti-photoaging and moisturizing effects of Bouea macrophylla extract (BRE). UVB-irradiated hairless mice were orally administered with BME (300 mg/kg/day) for 8 weeks. BME ameliorated wrinkle formation, skin thickening, and inelasticity. BME upregulated COL1A1, COL3A1, COL4A1, and COL7A1 mRNA levels through activation of the transforming growth factor-β (TGF-β)/Smad pathway, thereby recovering the content of collagen reduced by UVB. Further, BME suppressed UVB-induced matrix metalloproteinase (MMP)-3 and MMP-13 expression and inhibited MMP-2 and MMP-9 activity by mediating the mitogen-activated protein kinases (MAPKs)/activator protein-1 (AP-1). BME improved moisture content by stimulating the expression of cornified envelope proteins and filaggrin-processing enzymes. Overall, the results show that BME prevents photoaging and promotes moisturization in UVB-irradiated hairless mice, suggesting its potential as a nutraceutical candidate for anti-photoaging and moisturizing effects.