Pathological alterations in the gastrointestinal tract of a porcine model of DMD
Here we employed the CRISPR/Cas9 system combined with somatic nuclear transfer technology (SCNT) to establish a porcine model of DMD and explored their pathological alterations. We found that genetic disruption of dystrophin expression led to morphological gastrointestinal tract alterations, weakene...
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Published in | Cell & bioscience Vol. 11; no. 1; pp. 1 - 131 |
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Main Authors | , , , , |
Format | Journal Article |
Language | English |
Published |
London
BioMed Central Ltd
15.07.2021
BioMed Central BMC |
Subjects | |
Online Access | Get full text |
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Summary: | Here we employed the CRISPR/Cas9 system combined with somatic nuclear transfer technology (SCNT) to establish a porcine model of DMD and explored their pathological alterations. We found that genetic disruption of dystrophin expression led to morphological gastrointestinal tract alterations, weakened the gastrointestinal tract digestion and absorption capacity, and eventually led to malnutrition and gastric dysfunction in the DMD pigs. This work provides important insights into the pathogenesis of DMD and highlights the need to consider the gastrointestinal dysfunction as an additional therapeutic target for DMD patients. |
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Bibliography: | ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 content type line 23 |
ISSN: | 2045-3701 2045-3701 |
DOI: | 10.1186/s13578-021-00647-9 |