Pathological alterations in the gastrointestinal tract of a porcine model of DMD

Here we employed the CRISPR/Cas9 system combined with somatic nuclear transfer technology (SCNT) to establish a porcine model of DMD and explored their pathological alterations. We found that genetic disruption of dystrophin expression led to morphological gastrointestinal tract alterations, weakene...

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Published inCell & bioscience Vol. 11; no. 1; pp. 1 - 131
Main Authors Zou, Xiaodong, Ouyang, Hongsheng, Pang, Daxin, Han, Renzhi, Tang, Xiaochun
Format Journal Article
LanguageEnglish
Published London BioMed Central Ltd 15.07.2021
BioMed Central
BMC
Subjects
Analysis
Animal models
Apoptosis
Autophagy
Cardiac muscle
Cardiomyopathy
CRISPR
Dehydrogenases
Duchenne muscular dystrophy
Duchenne's muscular dystrophy
Dystrophin
Gastrointestinal diseases
Gastrointestinal system
Gastrointestinal tract
Gene expression
Genome editing
Genomics
Health aspects
Hogs
Kinases
Malnutrition
Muscles
Muscular dystrophy
Musculoskeletal system
Mutation
Nuclear transfer
Pig
Porcine
Proteins
Skeletal muscle
Smooth muscle
Swine
Therapeutic targets
Utrophin
China
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Summary:Here we employed the CRISPR/Cas9 system combined with somatic nuclear transfer technology (SCNT) to establish a porcine model of DMD and explored their pathological alterations. We found that genetic disruption of dystrophin expression led to morphological gastrointestinal tract alterations, weakened the gastrointestinal tract digestion and absorption capacity, and eventually led to malnutrition and gastric dysfunction in the DMD pigs. This work provides important insights into the pathogenesis of DMD and highlights the need to consider the gastrointestinal dysfunction as an additional therapeutic target for DMD patients.
Bibliography:ObjectType-Article-1
SourceType-Scholarly Journals-1
ObjectType-Feature-2
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ISSN:2045-3701
2045-3701
DOI:10.1186/s13578-021-00647-9