Antitussive Use in Patients with Inadequately Controlled Moderate-to-Severe Asthma: A Post Hoc Analysis of the Omalizumab EXTRA Trial

Acute and chronic cough are common symptoms in patients with severe allergic asthma. Although asthma-related cough can be controlled by asthma-specific medications, both prescription and over-the-counter antitussives are often also necessary. The anti-immunoglobulin E monoclonal antibody omalizumab...

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Published inJournal of asthma and allergy Vol. 16; pp. 661 - 665
Main Authors Rutland, Cedric J, Iweala, Onyinye I, Anders, Kyle, Ko, Jinnie, Mital, Parul, Gupta, Sachin, Mohan, Arjun
Format Journal Article
LanguageEnglish
Published New Zealand Dove Medical Press Limited 01.01.2023
Dove
Dove Medical Press
Subjects
Analysis
antitussive
Asthma
Biotechnology industry
Care and treatment
cough
Medical research
Medicine, Experimental
Nonprescription drugs
Omalizumab
Short Report
Tiotropium
Switzerland
asthma
omalizumab
antitussive
cough
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Summary:Acute and chronic cough are common symptoms in patients with severe allergic asthma. Although asthma-related cough can be controlled by asthma-specific medications, both prescription and over-the-counter antitussives are often also necessary. The anti-immunoglobulin E monoclonal antibody omalizumab is an effective treatment for patients with moderate-to-severe asthma, but little is known about subsequent antitussive use patterns. This post hoc analysis examined data from the Phase 3 EXTRA study that included patients aged 12-75 years with inadequately controlled moderate-to-severe asthma. Baseline antitussive use was low overall (16/427, 3.7% for omalizumab and 18/421, 4.3% for placebo). Among patients with no baseline antitussive use (n = 411 omalizumab, n = 403 placebo), most patients (88.3% omalizumab, 83.4% placebo) reported not using antitussives during the 48-week treatment period. The percentage of patients using 1 antitussive was lower for patients treated with omalizumab than placebo (7.1% vs 13.2%), although the adjusted rate of antitussive use during the treatment period was similar for omalizumab and placebo (0.22 and 0.25). Non-narcotics were used more often than narcotics. In conclusion, this analysis found low use of antitussives in patients with severe asthma and suggests that omalizumab may have the potential to decrease antitussive use.
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ISSN:1178-6965
1178-6965
DOI:10.2147/JAA.S412762