Hypolipidemic and anti-inflammatory properties of Abacopterin A from Abacopteris penangiana in high-fat diet-induced hyperlipidemia mice

• Published in: Food and chemical toxicology Vol. 49; no. 12; pp. 3206 - 3210
• Main Authors: Lei, Yong-Fang, Chen, Jing-Lou, Wei, Han, Xiong, Chao-Mei, Zhang, Yong-Hui, Ruan, Jin-Lan
• Format: Journal Article
• Language: English
• Published: Oxford Elsevier Ltd 01.12.2011; Elsevier
• Subjects: Abacopterin A; Animals; Anthocyanins - pharmacology; anti-inflammatory activity; Anti-Inflammatory Agents - pharmacology; Biological and medical sciences; cholesterol; Cholesterol - blood; Diet, High-Fat; Dietary Fats - administration & dosage; Disorders of blood lipids. Hyperlipoproteinemia; Ferns - chemistry; flavonoids; Gene Expression Regulation; Glycosides - pharmacology; High-fat diet; hyperlipidemia; Hyperlipidemias - chemically induced; Hyperlipidemias - drug therapy; Hypolipidemic; Hypolipidemic Agents - pharmacology; inflammation; Inflammatory; interleukin-6; Interleukin-6 - blood; Lipoprotein lipase; Lipoprotein Lipase - metabolism; Male; Medical sciences; Metabolic diseases; Mice; Mice, Inbred C57BL; NF-kappa B - genetics; NF-kappa B - metabolism; NFκB; oral administration; Phytotherapy; Plant Extracts - pharmacology; Toxicology; transcription factor NF-kappa B; triacylglycerols; Triglycerides - blood; tumor necrosis factor-alpha; Tumor Necrosis Factor-alpha - blood; Hypolipidemic; Inflammatory; Lipoprotein lipase; Abacopterin A; NFκB; High-fat diet; Lipids; Esterases; EC 3.1.1.34; Hyperlipemia; Transcription factor NFκB; Dyslipemia; Nutrition; Enzyme; Biochemical compound; Rodentia; Antiinflammatory agent; Metabolic diseases; Inflammation; Carboxylic ester hydrolases; Feeding; Vertebrata; Mammalia; Diet; Mouse; Animal; Fat; Hydrolases; Antilipemic agent
• ISSN: 0278-6915; 1873-6351
• DOI: 10.1016/j.fct.2011.08.027

Abacopterin A (APA) was isolated from Abacopteris penangiana using bioassay-guided fractionation. The aim of this study was to investigate the probable mechanisms of the hypolipidemic and anti-inflammatory properties of Abacopterin A in high-fat diet-induced hyperlipidemia mice. [Display omitted] . ► Hypolipidemic and anti-inflammatory properties of Abacopterin A. ► Abacopterin A inhibited the NFκB dependent inflammatory response. ► Abacopterin A increased the activities of LPL and HL. This study was to investigate the hypolipidemic and anti-inflammatory properties of Abacopterin A (APA), a flavonoid compound isolated from Abacopteris penangiana (Hook.) Ching. Male C57BL/6J mice were divided randomly and equally into five groups: the normal control group (N), the model group (M), the positive control group (P), the high and low doses of APA treated groups (H and L). All the animals except that in N group were fed with high-fat diet for 8weeks. In the last 4weeks, the mice in P, H and L groups were orally administered with simvastatin (at the dose of 20mg/kg/day) and APA (at the dose of 40 or 20mg/kg/day), respectively. Then the lipid profiles and related biochemical criterions of the studied mice were determined. The effects of high-fat diet on activating nuclear transcription factor-κB (NFκB) expression, elevating inflammatory factors tumor necrosis factor-alpha (TNF-α) and interleukin-6 (IL-6) levels, and increasing triacylglycerol (TG) and total cholesterol (TC) levels were abolished on daily supplementation with APA. APA also enhanced lipoprotein lipase (LPL) and hepatic lipase (HL) activities. These results suggested that APA had hypolipidemic and anti-inflammatory properties through inhibiting NFκB expression, and reducing inflammatory response.