Redox and pH Responsive Poly (Amidoamine) Dendrimer-Heparin Conjugates via Disulfide Linkages for Letrozole Delivery

• Published in: BioMed research international Vol. 2017; no. 2017; pp. 1 - 7
• Main Authors: Hai, Nguyen Dai, Nguyen, Cuu Khoa, Nguyen, Thi Hiep, Nguyen, Thanh Luan
• Format: Journal Article
• Language: English
• Published: Cairo, Egypt Hindawi Publishing Corporation 01.01.2017; Hindawi; Hindawi Limited
• Subjects: Biocompatibility; Chemical bonds; Dendrimers - chemistry; Disulfides - chemistry; Drug delivery systems; Drug Delivery Systems - methods; Drug Liberation; Dynamic Light Scattering; Efficiency; Heparin - chemistry; Hydrogen-Ion Concentration; Materials science; Microscopy, Electron, Transmission; Nanoparticles; Nitriles - chemical synthesis; Nitriles - chemistry; Nitriles - pharmacology; NMR; Nuclear magnetic resonance; Oxidation-Reduction; Particle Size; Polyamines - chemistry; Proton Magnetic Resonance Spectroscopy; Static Electricity; Studies; Triazoles - chemical synthesis; Triazoles - chemistry; Triazoles - pharmacology
• ISSN: 2314-6133; 2314-6141
• DOI: 10.1155/2017/8589212

Heparin (Hep) conjugated to poly (amidoamine) dendrimer G3.5 (P) via redox-sensitive disulfide bond (P-SS-Hep) was studied. The redox and pH dual-responsive nanocarriers were prepared by a simple method that minimized many complex steps as previous studies. The functional characterization of G3.5 coated Hep was investigated by the proton nuclear magnetic resonance spectroscopy. The size and formation were characterized by the dynamic light scattering, zeta potential, and transmission electron microscopy. P-SS-Hep was spherical in shape with average diameter about 11 nm loaded with more than 20% letrozole. This drug carrier could not only eliminate toxicity to cells and improve the drugs solubility but also increase biocompatibility of the system under reductive environment of glutathione. In particular, P-SS-Hep could enhance the effectiveness of cancer therapy after removing Hep from the surface. These results demonstrated that the P-SS-Hep conjugates could be a promising candidate as redox and pH responsive nanocarriers for cancer chemotherapy.