MUC-1 expression in pleomorphic adenomas using two human milk fat globule protein membrane antibodies (HMFG-1 and HMFG-2)

• Published in: Journal of applied oral science Vol. 23; no. 3; pp. 265 - 271
• Main Authors: Ponce-Bravo, Santa, Ledesma-Montes, Constantino, Garcés-Ortíz, Maricela
• Format: Journal Article
• Language: English
• Published: Brazil Faculdade de Odontologia de Bauru da Universidade de São Paulo 01.06.2015; Faculdade De Odontologia De Bauru - USP; University of São Paulo
• Subjects: Adenoma, Pleomorphic - chemistry; Adenoma, Pleomorphic - pathology; Antibodies, Monoclonal; Biomarkers, Tumor - analysis; Case-Control Studies; Dentistry; DENTISTRY, ORAL SURGERY & MEDICINE; Glycolipids; Glycoproteins; Human milk fat globule membrane; Humans; Immunohistochemistry; Membrane Proteins; MUC-1 mucin; Mucin-1 - analysis; Myoepithelial cell; Original; Paraffin Embedding; Pleomorphic adenoma; Reference Values; Salivary Gland Neoplasms - chemistry; Salivary Gland Neoplasms - pathology; Salivary gland tumors; Salivary Glands - chemistry; Salivary Glands - secretion; Staining and Labeling - methods; Human milk fat globule membrane; Myoepithelial cell; MUC-1 mucin; Salivary gland tumors; Pleomorphic adenoma

Pleomorphic adenoma (PA) is the most common salivary gland tumor and its microscopic features and histogenesis are a matter of debate. Human milk fat globule protein membrane (HMFG) monoclonal antibodies (MoAbs) comprise a set of antibodies against the mucin 1 (MUC-1) protein detected in several sal...