The structural dynamics of macromolecular processes

Dynamic processes involving macromolecular complexes are essential to cell function. These processes take place over a wide variety of length scales from nanometers to micrometers, and over time scales from nanoseconds to minutes. As a result, information from a variety of different experimental and...

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Published inCurrent opinion in cell biology Vol. 21; no. 1; pp. 97 - 108
Main Authors Russel, Daniel, Lasker, Keren, Phillips, Jeremy, Schneidman-Duhovny, Dina, Velázquez-Muriel, Javier A, Sali, Andrej
Format Journal Article
LanguageEnglish
Published England Elsevier Ltd 01.02.2009
Subjects
Cell Physiological Phenomena
Computer Simulation
Internal Medicine
Macromolecular Substances - metabolism
Models, Biological
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Summary:Dynamic processes involving macromolecular complexes are essential to cell function. These processes take place over a wide variety of length scales from nanometers to micrometers, and over time scales from nanoseconds to minutes. As a result, information from a variety of different experimental and computational approaches is required. We review the relevant sources of information and introduce a framework for integrating the data to produce representations of dynamic processes.
Bibliography:ObjectType-Article-1
SourceType-Scholarly Journals-1
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ObjectType-Review-2
ISSN:0955-0674
1879-0410
DOI:10.1016/j.ceb.2009.01.022