Relationship between peak serum estradiol levels and treatment outcome in in vitro fertilization cycles after embryo transfer on day 3 or day 5

• Published in: Fertility and sterility Vol. 80; no. 1; pp. 75 - 79
• Main Authors: Chen, Chi-Huang, Zhang, Xingqi, Barnes, Randall, Confino, Edmond, Milad, Magdy, Puscheck, Elizabeth, Kazer, Ralph R
• Format: Journal Article
• Language: English
• Published: New York, NY Elsevier Inc 01.07.2003; Elsevier Science
• Subjects: Adult; Biological and medical sciences; Birth control; Blastocyst - physiology; blastocyst transfer; Embryo Implantation - physiology; Embryo Transfer; Estradiol - blood; Estradiol level in serum; Female; Fertilization in Vitro - methods; Gynecology. Andrology. Obstetrics; Humans; Male; Medical sciences; Pregnancy; Pregnancy Outcome; pregnancy rates; Retrospective Studies; Sterility. Assisted procreation; Time Factors; Treatment Outcome; Estradiol level in serum; blastocyst transfer; pregnancy rates; Human; blastocyst transfer pregnancy rates; Estrogen; Blastocyst; Assisted procreation; Estradiol; In vitro; Ovarian hormone; In vitro fertilization embryo transfer; Pregnancy; Embryo transfer; Embryo culture; Female; Sex steroid hormone
• ISSN: 0015-0282; 1556-5653
• DOI: 10.1016/S0015-0282(03)00504-1

To examine the relationships between peak serum estradiol (E 2) levels and treatment outcome in in vitro fertilization (IVF) cycles after embryo transfer (ET) on day 3 or day 5. Retrospective analysis of 697 IVF-ET cycles between January 1999 and December 2001. A university-affiliated assisted reproduction program. Infertile patients undergoing IVF-ET cycles. Peak E 2 concentration in serum was determined on the day of human chorionic gonadotropin (hCG) administration. The IVF-generated embryos were cultured for 2 days until transfer on day 3. If more than four 8-cell embryos were present on day 3, embryo culture was continued until day 5 for blastocyst transfer. Clinical pregnancy rates. High peak E 2 levels did not adversely affect treatment outcome. After the cycles were divided according to the day of ET, high peak E 2 levels were associated with improved pregnancy rates after ET on day 5 but not on day 3. Increasing peak E 2 levels in IVF cycles are associated with improved pregnancy rates after ET on day 5.